| Literature DB >> 19450644 |
Lindvi Gudmundsdotter1, Charlotta Nilsson, Andreas Brave, Bo Hejdeman, Patricia Earl, Bernard Moss, Merlin Robb, Josephine Cox, Nelson Michael, Mary Marovich, Gunnel Biberfeld, Eric Sandström, Britta Wahren.
Abstract
The presence of vector-specific immune responses may hamper the induction of responses to a foreign antigen encoded by the vector. We evaluated the impact of pre-existing immunity to vaccinia virus on the induction of HIV-specific responses after immunization of healthy volunteers with a HIV-1 DNA prime-MVA boost vaccine. Following three priming immunizations with HIV-1 DNA plasmids, the volunteers were boosted with a single injection of recombinant MVA encoding HIV-1 proteins. Pre-existing immunity to vaccinia virus did not reduce the proportion of individuals who responded to HIV-1, but did lower the magnitude of responses. Our results suggest that vaccinia-based vectors can be used to efficiently induce immune responses to vectored HIV-1 antigens, even in individuals with pre-existing immunity to vaccinia virus.Entities:
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Year: 2009 PMID： 19450644 PMCID： PMC4788966 DOI： 10.1016/j.vaccine.2009.05.018
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641