OBJECTIVES: We sought to evaluate the usefulness of a comprehensive assessment of four cardiovascular magnetic resonance imaging (CMR)-derived myocardial viability indexes in the setting of myocardial stunning. BACKGROUND: Cardiovascular magnetic resonance imaging allows the simultaneous assessment of several viability indexes. METHODS: We studied 40 patients with a first ST-segment elevation myocardial infarction (MI) and an open infarct-related artery. At the first week, using CMR, wall motion (WM), and four viability indexes were determined: wall thickness, WM improvement with low-dose dobutamine, perfusion, and transmural extent of necrosis. We created a comprehensive score based on the presence and the relative power of these viability indexes for predicting normal WM at the sixth month. RESULTS: Of 153 dysfunctional segments at the first week, 59 (39%) exhibited normal WM at the sixth month. According to the odds ratio of viability indexes for predicting normal WM, we developed a five-level predictive score. The proportions of segments showing normal WM at sixth month were as follows; Level 1 (0 indexes): 0 of 13 (0%); Level 2 (normal thickness and/or perfusion): 14 of 82 (17%); Level 3 (dobutamine response): 5 of 11 (45%); Level 4 (non-transmural necrosis): 20 of 26 (77%); Level 5 (non-transmural necrosis and dobutamine response): 20 of 21 (95%), p < 0.0001 for the trend. These proportions were similar in a matched prospective validation group comprising 16 patients (0%, 18%, 62%, 77%, and 90% for levels 1 to 5, respectively, p < 0.0001 for the trend). CONCLUSIONS: A comprehensive analysis of the four more widely used CMR-derived viability indexes is useful for predicting late systolic function after myocardial infarction.
OBJECTIVES: We sought to evaluate the usefulness of a comprehensive assessment of four cardiovascular magnetic resonance imaging (CMR)-derived myocardial viability indexes in the setting of myocardial stunning. BACKGROUND: Cardiovascular magnetic resonance imaging allows the simultaneous assessment of several viability indexes. METHODS: We studied 40 patients with a first ST-segment elevation myocardial infarction (MI) and an open infarct-related artery. At the first week, using CMR, wall motion (WM), and four viability indexes were determined: wall thickness, WM improvement with low-dose dobutamine, perfusion, and transmural extent of necrosis. We created a comprehensive score based on the presence and the relative power of these viability indexes for predicting normal WM at the sixth month. RESULTS: Of 153 dysfunctional segments at the first week, 59 (39%) exhibited normal WM at the sixth month. According to the odds ratio of viability indexes for predicting normal WM, we developed a five-level predictive score. The proportions of segments showing normal WM at sixth month were as follows; Level 1 (0 indexes): 0 of 13 (0%); Level 2 (normal thickness and/or perfusion): 14 of 82 (17%); Level 3 (dobutamine response): 5 of 11 (45%); Level 4 (non-transmural necrosis): 20 of 26 (77%); Level 5 (non-transmural necrosis and dobutamine response): 20 of 21 (95%), p < 0.0001 for the trend. These proportions were similar in a matched prospective validation group comprising 16 patients (0%, 18%, 62%, 77%, and 90% for levels 1 to 5, respectively, p < 0.0001 for the trend). CONCLUSIONS: A comprehensive analysis of the four more widely used CMR-derived viability indexes is useful for predicting late systolic function after myocardial infarction.
Authors: Oliver Husser; Vicente Bodi; Juan Sanchis; Julio Nunez; Luis Mainar; Pilar Merlos; Maria P Lopez-Lereu; Jose V Monmeneu; Fabian Chaustre; Eva Rumiz; Günter A J Riegger; Francisco J Chorro; Angel Llacer Journal: Int J Cardiovasc Imaging Date: 2010-02-20 Impact factor: 2.357
Authors: Oliver Husser; Fabian Chaustre; Juan Sanchis; Julio Nunez; Jose V Monmeneu; Maria P Lopez-Lereu; Clara Bonanad; Cristina Gomez; Ricardo Oltra; Angel Llacer; Günter A J Riegger; Francisco J Chorro; Vicente Bodi Journal: Int J Cardiovasc Imaging Date: 2012-01-20 Impact factor: 2.357
Authors: V Bodí; J Sanchis; M P López-Lereu; J Núñez; R Sanz; P Palau; C Gómez; D Moratal; F J Chorro; A Llácer Journal: Heart Date: 2006-06-27 Impact factor: 5.994
Authors: L Natale; C Napolitano; A Bernardini; A Meduri; R Marano; A Lombardo; F Crea; L Bonomo Journal: Radiol Med Date: 2012-03-19 Impact factor: 3.469
Authors: Oliver Husser; Vicente Bodi; Juan Sanchis; Julio Nunez; Luis Mainar; Francisco Javier Chorro; Maria Pilar Lopez-Lereu; Jose Vicente Monmeneu; Fabian Chaustre; Maria J Forteza; Isabel Trapero; Francisco Dasi; Isabel Benet; Günter A J Riegger; Angel Llacer Journal: Inflammation Date: 2011-04 Impact factor: 4.092
Authors: Oliver Husser; Jose V Monmeneu; Clara Bonanad; Cristina Gomez; Fabian Chaustre; Julio Nunez; Maria P Lopez-Lereu; Gema Minana; Juan Sanchis; Luis Mainar; Vicente Ruiz; Maria J Forteza; Isabel Trapero; David Moratal; Francisco J Chorro; Vicente Bodi Journal: Int J Cardiovasc Imaging Date: 2013-06-04 Impact factor: 2.357