Literature DB >> 16253876

Microfluidic technologies in drug discovery.

Johan Pihl1, Mattias Karlsson, Daniel T Chiu.   

Abstract

Microfluidic systems are increasingly used as tools in various stages of the drug discovery process. Microscale systems offer several obvious advantages, such as low sample consumption and significantly reduced analysis or experiment time. These technologies raise the possibility of massive parallelization and concomitant reduction in cost per acquired data point. In addition, fluids in confined spaces display unique behaviors that can be used to acquire information not accessible using macroscopic systems. This article will focus on the implementation of microfluidic systems and technologies in the process of drug discovery.

Mesh:

Year:  2005        PMID: 16253876     DOI: 10.1016/S1359-6446(05)03571-3

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  14 in total

1.  Electromechanical properties of pressure-actuated poly(dimethylsiloxane) microfluidic push-down valves.

Authors:  Hao Chen; Wei Gu; Nick Cellar; Robert Kennedy; Shuichi Takayama; Jens-Christian Meiners
Journal:  Anal Chem       Date:  2008-06-25       Impact factor: 6.986

2.  Diffusion phenomena of cells and biomolecules in microfluidic devices.

Authors:  Ece Yildiz-Ozturk; Ozlem Yesil-Celiktas
Journal:  Biomicrofluidics       Date:  2015-07-01       Impact factor: 2.800

3.  The potential impact of droplet microfluidics in biology.

Authors:  Thomas Schneider; Jason Kreutz; Daniel T Chiu
Journal:  Anal Chem       Date:  2013-03-15       Impact factor: 6.986

4.  Ultraviolet-assisted microfluidic generation of ferroelectric composite particles.

Authors:  Cancan Zhang; Xiaolei Yu; Sujian You; Bo Cai; Huiqin Liu; Lingling Zhang; Lang Rao; Wei Liu; Shi-Shang Guo; Xing-Zhong Zhao
Journal:  Biomicrofluidics       Date:  2016-03-15       Impact factor: 2.800

5.  Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

Authors:  John R Goodell; Jonathan P McMullen; Nikolay Zaborenko; Jason R Maloney; Chuan-Xing Ho; Klavs F Jensen; John A Porco; Aaron B Beeler
Journal:  J Org Chem       Date:  2009-08-21       Impact factor: 4.354

Review 6.  Microfluidic epigenomic mapping technologies for precision medicine.

Authors:  Chengyu Deng; Lynette B Naler; Chang Lu
Journal:  Lab Chip       Date:  2019-07-24       Impact factor: 6.799

7.  Size selective sampling using mobile, 3D nanoporous membranes.

Authors:  Christina L Randall; Aubri Gillespie; Siddarth Singh; Timothy G Leong; David H Gracias
Journal:  Anal Bioanal Chem       Date:  2008-12-10       Impact factor: 4.142

8.  Fuming method for micropatterning structures on Langmuir-Blodgett films.

Authors:  Elizabeth S Erickson; Philip W Livanec; Jessica F Frisz; Robert C Dunn
Journal:  Langmuir       Date:  2009-05-05       Impact factor: 3.882

9.  Distributed colorimetric interferometer for mapping the pressure distribution in a complex microfluidics network.

Authors:  Xiongfeng Zhu; Tianxing Man; Xing Haw Marvin Tan; Pei-Shan Chung; Michael A Teitell; Pei-Yu Chiou
Journal:  Lab Chip       Date:  2021-01-18       Impact factor: 6.799

Review 10.  Cell-Based Biosensors: Electrical Sensing in Microfluidic Devices.

Authors:  Katrine Kiilerich-Pedersen; Noemi Rozlosnik
Journal:  Diagnostics (Basel)       Date:  2012-12-06
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