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Literature DB >> 16251403

Rous-Whipple Award Lecture. The Alzheimer's brain: finding out what's broken tells us how to fix it.

John Q Trojanowski¹, Virginia M-Y Lee.

Abstract

Entities: Disease

Mesh：

Substances：
tau Proteins

Year: 2005 PMID： 16251403 PMCID： PMC1603781 DOI： 10.1016/s0002-9440(10)61206-0

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

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31 in total

Review 1. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease.

Authors: Shermali Gunawardena; Lawrence S B Goldstein
Journal: J Neurobiol Date: 2004-02-05

2. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform.

Authors: T Ishihara; M Hong; B Zhang; Y Nakagawa; M K Lee; J Q Trojanowski; V M Lee
Journal: Neuron Date: 1999-11 Impact factor: 17.173

3. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.

Authors: Bin Zhang; Arpita Maiti; Sharon Shively; Fara Lakhani; Gaye McDonald-Jones; Jennifer Bruce; Edward B Lee; Sharon X Xie; Sonali Joyce; Chi Li; Philip M Toleikis; Virginia M-Y Lee; John Q Trojanowski
Journal: Proc Natl Acad Sci U S A Date: 2004-12-22 Impact factor: 11.205

Review 4. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

Authors: Yoo-Hun Suh; Frederic Checler
Journal: Pharmacol Rev Date: 2002-09 Impact factor: 25.468

Review 5. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs.

Authors: Mark S Forman; John Q Trojanowski; Virginia M-Y Lee
Journal: Nat Med Date: 2004-10 Impact factor: 53.440

6. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Authors: Christopher J Phiel; Christina A Wilson; Virginia M-Y Lee; Peter S Klein
Journal: Nature Date: 2003-05-22 Impact factor: 49.962

7. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

Authors: V M Lee; B J Balin; L Otvos; J Q Trojanowski
Journal: Science Date: 1991-02-08 Impact factor: 47.728

8. Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).

Authors: G T Bramblett; J Q Trojanowski; V M Lee
Journal: Lab Invest Date: 1992-02 Impact factor: 5.662

Review 5. Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?

Authors: Xinyi Li; Joel N Buxbaum
Journal: Mol Neurodegener Date: 2011-11-23 Impact factor: 14.195

5 in total

Rous-Whipple Award Lecture. The Alzheimer's brain: finding out what's broken tells us how to fix it.

Review 1. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease.

2. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform.

3. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.

Review 4. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

Review 5. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs.

6. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

7. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

8. Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).

9. Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses.

Review 10. Axonal transport of membranous and nonmembranous cargoes: a unified perspective.

1. The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease.

Review 2. Single cell gene expression profiling in Alzheimer's disease.

Review 3. Target identification for CNS diseases by transcriptional profiling.

Review 4. Nuclear and cytosolic JNK signalling in neurons.

Review 5. Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?