Literature DB >> 16251337

New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.

W J Suling1, L E Seitz, R C Reynolds, W W Barrow.   

Abstract

Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16251337      PMCID： PMC1280141          DOI： 10.1128/AAC.49.11.4801-4803.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.

Authors:  G B ELION; S SINGER; G H HITCHINGS
Journal:  J Biol Chem       Date:  1954-06       Impact factor: 5.157

2.  Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase.

Authors:  G H Hitchings
Journal:  In Vitro Cell Dev Biol       Date:  1989-04

3.  Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium.

Authors:  L Collins; S G Franzblau
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

4.  Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate reductase.

Authors:  W J Suling; R C Reynolds; E W Barrow; L N Wilson; J R Piper; W W Barrow
Journal:  J Antimicrob Chemother       Date:  1998-12       Impact factor: 5.790

Review 5.  Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors.

Authors:  P G Hartman
Journal:  J Chemother       Date:  1993-12       Impact factor: 1.714

6.  Antimycobacterial activities of 2,4-diamino-5-deazapteridine derivatives and effects on mycobacterial dihydrofolate reductase.

Authors:  W J Suling; L E Seitz; V Pathak; L Westbrook; E W Barrow; S Zywno-Van-Ginkel; R C Reynolds; J R Piper; W W Barrow
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191
  6 in total
  2 in total

1.  Sedation practices for routine diagnostic upper gastrointestinal endoscopy in Nigeria.

Authors:  Sylvester Chuks Nwokediuko; Olive Obienu
Journal:  World J Gastrointest Endosc       Date:  2012-06-16

2.  A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria.

Authors:  Deborah Mai; Jennifer Jones; John W Rodgers; John L Hartman; Olaf Kutsch; Adrie J C Steyn
Journal:  Assay Drug Dev Technol       Date:  2011-01-31       Impact factor: 1.738
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.