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Literature DB >> 16251328

mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis.

Maria R Pasca¹, Paola Guglierame, Edda De Rossi, Francesca Zara, Giovanna Riccardi.

Abstract

The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the mmpL7 gene was observed.

Entities: Chemical Species

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Year: 2005 PMID： 16251328 PMCID： PMC1280163 DOI： 10.1128/AAC.49.11.4775-4777.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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