Literature DB >> 16249093

Substituted phenanthrenes with basic amino side chains: a new series of anti-breast cancer agents.

Ajay Kumar Srivastava, Ramesh Sharma, Rajeev Mishra, Anil Kumar Balapure, Puvvada S R Murthy, Gautam Panda.   

Abstract

In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC(50) in the range of 3.53-22.25 microM. One of the compounds 15 ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.

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Year:  2005        PMID： 16249093     DOI： 10.1016/j.bmc.2005.10.002

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  17 in total

1.  CoMFA and CoMSIA 3D-QSAR analysis of diaryloxy-methano-phenanthrene derivatives as anti-tubercular agents.

Authors:  Ashutosh Kumar; Gautam Panda; Mohammad Imran Siddiqi
Journal:  J Mol Model       Date:  2006-06-21       Impact factor: 1.810

2.  Retention or inversion in stereospecific nickel-catalyzed cross-coupling of benzylic carbamates with arylboronic esters: control of absolute stereochemistry with an achiral catalyst.

Authors:  Michael R Harris; Luke E Hanna; Margaret A Greene; Curtis E Moore; Elizabeth R Jarvo
Journal:  J Am Chem Soc       Date:  2013-02-22       Impact factor: 15.419

3.  Asymmetric transition metal-catalyzed cross-coupling reactions for the construction of tertiary stereocenters.

Authors:  Elizabeth C Swift; Elizabeth R Jarvo
Journal:  Tetrahedron       Date:  2013-07-22       Impact factor: 2.457

4.  Selective synthesis of either enantiomer of an anti-breast cancer agent via a common enantioenriched intermediate.

Authors:  Aaron George Johnson; Marissa M Tranquilli; Michael R Harris; Elizabeth R Jarvo
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

5.  Antibacterial and antioxidant assay of novel heteroaryl-substituted methane derivatives synthesized via ceric ammonium nitrate (CAN) catalyzed one-pot green approach.

Authors:  Monika Verma; Ajay Thakur; Shikha Kapil; Renu Sharma; Ajay Sharma; Ruchi Bharti
Journal:  Mol Divers       Date:  2022-07-03       Impact factor: 2.943

6.  Synthesis of Triarylmethanes via Palladium-Catalyzed Suzuki-Miyaura Reactions of Diarylmethyl Esters.

Authors:  Amira H Dardir; Irene Casademont-Reig; David Balcells; Jonathan D Ellefsen; Matthew R Espinosa; Nilay Hazari; Nicholas E Smith
Journal:  Organometallics       Date:  2021-05-27       Impact factor: 3.837

7.  Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

Authors:  Dianqing Sun; Michael S Scherman; Victoria Jones; Julian G Hurdle; Lisa K Woolhiser; Susan E Knudson; Anne J Lenaerts; Richard A Slayden; Michael R McNeil; Richard E Lee
Journal:  Bioorg Med Chem       Date:  2009-04-09       Impact factor: 3.641

8.  Antiplasmodial activity of [(aryl)arylsulfanylmethyl]Pyridine.

Authors:  Sanjay Kumar; Sajal Kumar Das; Sumanta Dey; Pallab Maity; Mithu Guha; Vinay Choubey; Gautam Panda; Uday Bandyopadhyay
Journal:  Antimicrob Agents Chemother       Date:  2007-11-19       Impact factor: 5.191

9.  Transition-Metal-Free Synthesis of Polyfunctional Triarylmethanes and 1,1-Diarylalkanes by Sequential Cross-Coupling of Benzal Diacetates with Organozinc Reagents.

Authors:  Baosheng Wei; Qianyi Ren; Thomas Bein; Paul Knochel
Journal:  Angew Chem Int Ed Engl       Date:  2021-03-17       Impact factor: 15.336

10.  NiXantphos: a deprotonatable ligand for room-temperature palladium-catalyzed cross-couplings of aryl chlorides.

Authors:  Jiadi Zhang; Ana Bellomo; Nisalak Trongsiriwat; Tiezheng Jia; Patrick J Carroll; Spencer D Dreher; Matthew T Tudge; Haolin Yin; Jerome R Robinson; Eric J Schelter; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2014-04-21       Impact factor: 15.419
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