Literature DB >> 16248062

Oxidation of biotin during oligonucleotide synthesis.

Krishna Upadhya1, Iqbal K Khattak, Bashar Mullah.   

Abstract

A new "polystyrene biotin support" has been synthesized for the solid support synthesis of the 3'-biotinylated oligonucleotides. Several oligos were synthesized and were analyzed by the HPLC and Mass Spec. Oligo analysis revealed that the biotin gets oxidized to "biotin sulfoxide" during the synthesis.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16248062     DOI： 10.1081/ncn-200059277

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  2 in total

1.  Synthesis of Site-Specific Crown Ether Adducts to DNA Abasic Sites: 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and 2'-Deoxycytidine.

Authors:  Na An; Aaron M Fleming; Nicole C Rosecrans; Yi Liao; Cynthia J Burrows
Journal:  Methods Mol Biol       Date:  2019

2.  Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes.

Authors:  Joji Grace Villamor; Farnusch Kaschani; Tom Colby; Julian Oeljeklaus; David Zhao; Markus Kaiser; Matthew P Patricelli; Renier A L van der Hoorn
Journal:  Mol Cell Proteomics       Date:  2013-05-29       Impact factor: 5.911
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.