Literature DB >> 16247996

A novel approach to solid phase chemical synthesis of oligonucleotide mRNA cap analogs.

Jacek Jemielity1, Petri Heinonen, Harri Lonnberg, Edward Darzynkiewicz.   

Abstract

A novel approach for the synthesis of 5-capped 2'-O-methyloligoribonucleotides on a disulfide-tethered solid support is described. The key step of the synthesis is ZnCl2 promoted coupling of m7GDP imidazolide to a fully deprotected oligonucleotide 5'-phosphate on-support. By this methodology m7G5'pppm2'Apm2'Upm2'Ap has been prepared.

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Year:  2005        PMID： 16247996     DOI： 10.1081/ncn-200061922

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  6 in total

1.  Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase.

Authors:  Yann Thillier; Etienne Decroly; François Morvan; Bruno Canard; Jean-Jacques Vasseur; Françoise Debart
Journal:  RNA       Date:  2012-02-14       Impact factor: 4.942

Review 2.  The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize.

Authors:  Miroslaw Janowski; Anna Andrzejewska
Journal:  Mol Ther Nucleic Acids       Date:  2022-07-13       Impact factor: 10.183

3.  5'-Terminal chemical capping of spliced leader RNAs.

Authors:  Karolina Piecyk; Richard E Davis; Marzena Jankowska-Anyszka
Journal:  Tetrahedron Lett       Date:  2012-07-04       Impact factor: 2.415

4.  High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions.

Authors:  F Peyrane; B Selisko; E Decroly; J J Vasseur; D Benarroch; B Canard; K Alvarez
Journal:  Nucleic Acids Res       Date:  2007-01-26       Impact factor: 16.971

Review 5.  Applications of Phosphate Modification and Labeling to Study (m)RNA Caps.

Authors:  Marcin Warminski; Pawel J Sikorski; Joanna Kowalska; Jacek Jemielity
Journal:  Top Curr Chem (Cham)       Date:  2017-01-23

Review 6.  Synthetic mRNA capping.

Authors:  Fabian Muttach; Nils Muthmann; Andrea Rentmeister
Journal:  Beilstein J Org Chem       Date:  2017-12-20       Impact factor: 2.883
  6 in total

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