Literature DB >> 16246556

4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.

Tadigoppula Narender1, Anju Puri, Tanvir Khaliq, Rashmi Saxena, Geetika Bhatia, Ramesh Chandra.   

Abstract

Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model.

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Year:  2005        PMID: 16246556     DOI: 10.1016/j.bmcl.2005.10.003

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  18 in total

1.  4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway.

Authors:  Natasha Jaiswal; Chandan K Maurya; K Venkateswarlu; P Sukanya; Arvind K Srivastava; Tadigoppula Narender; Akhilesh K Tamrakar
Journal:  Eur J Nutr       Date:  2012-05-19       Impact factor: 5.614

Review 2.  Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome.

Authors:  Scott Fuller; Jacqueline M Stephens
Journal:  Adv Nutr       Date:  2015-03-13       Impact factor: 8.701

3.  An overview of Indian novel traditional medicinal plants with anti-diabetic potentials.

Authors:  Rahul Gupta; Kumar Gaurav Bajpai; Samta Johri; A M Saxena
Journal:  Afr J Tradit Complement Altern Med       Date:  2007-10-27

4.  Activation of IGF-1/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity.

Authors:  Ambika Shandilya; Sidharth Mehan; Sumit Kumar; Pranshul Sethi; Acharan S Narula; Abdulrahman Alshammari; Metab Alharbi; Abdullah F Alasmari
Journal:  Molecules       Date:  2022-06-16       Impact factor: 4.927

5.  Fenugreek increases insulin-stimulated creatine content in L6C11 muscle myotubes.

Authors:  Kristyen A Tomcik; William J Smiles; Donny M Camera; Helmut M Hügel; John A Hawley; Rani Watts
Journal:  Eur J Nutr       Date:  2016-01-05       Impact factor: 5.614

6.  4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1.

Authors:  Sudeep Gautam; Nayab Ishrat; Pragya Yadav; Rohit Singh; Tadigoppula Narender; Arvind K Srivastava
Journal:  Mol Cell Biochem       Date:  2016-02-18       Impact factor: 3.396

7.  Reconstitution of TCA cycle involving l-isoleucine dioxygenase for hydroxylation of l-isoleucine in Escherichia coli using CRISPR-Cas9.

Authors:  Jianhong An; Wenli Zhang; Xiaoran Jing; Yao Nie; Yan Xu
Journal:  3 Biotech       Date:  2020-03-13       Impact factor: 2.406

8.  Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry.

Authors:  Geetika Wadhwa; Kowthavarapu Venkata Krishna; Rajeev Taliyan; Neeraj Tandon; Satyapal Singh Yadav; Chandrakant Katiyar; Sunil Kumar Dubey
Journal:  RSC Adv       Date:  2020-02-04       Impact factor: 4.036

9.  4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression.

Authors:  Feng Gao; Wen Du; Mohammad Ishraq Zafar; Raja Adeel Shafqat; Liumeng Jian; Qin Cai; Furong Lu
Journal:  Drug Des Devel Ther       Date:  2015-10-20       Impact factor: 4.162

10.  Fenugreek Prevents the Development of STZ-Induced Diabetic Nephropathy in a Rat Model of Diabetes.

Authors:  Yingli Jin; Yan Shi; Yinggang Zou; Chunsheng Miao; Bo Sun; Cai Li
Journal:  Evid Based Complement Alternat Med       Date:  2014-05-08       Impact factor: 2.629

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