| Literature DB >> 16246553 |
Zheng Yin1, Sejal J Patel, Wei-Ling Wang, Gang Wang, Wai-Ling Chan, K R Ranga Rao, Jenefer Alam, Duraiswamy A Jeyaraj, Xinyi Ngew, Viral Patel, David Beer, Siew Pheng Lim, Subhash G Vasudevan, Thomas H Keller.
Abstract
Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic acid. A boronic acid has the highest affinity, exhibiting a K(i) of 43 nM.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16246553 DOI： 10.1016/j.bmcl.2005.09.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823