Literature DB >> 27198478

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors.

Chao Shan1, Xuping Xie1, Antonio E Muruato2, Shannan L Rossi3, Christopher M Roundy2, Sasha R Azar2, Yujiao Yang1, Robert B Tesh3, Nigel Bourne4, Alan D Barrett5, Nikos Vasilakis3, Scott C Weaver6, Pei-Yong Shi7.   

Abstract

The Asian lineage of Zika virus (ZIKV) has recently caused epidemics and severe disease. Unraveling the mechanisms causing increased viral transmissibility and disease severity requires experimental systems. We report an infectious cDNA clone of ZIKV that was generated using a clinical isolate of the Asian lineage. The cDNA clone-derived RNA is infectious in cells, generating recombinant ZIKV. The recombinant virus is virulent in established ZIKV mouse models, leading to neurological signs relevant to human disease. Additionally, recombinant ZIKV is infectious for Aedes aegypti and thus provides a means to examine virus transmission. The infectious cDNA clone was further used to generate a luciferase ZIKV that exhibited sensitivity to a panflavivirus inhibitor, highlighting its potential utility for antiviral screening. This ZIKV reverse genetic system, together with mouse and mosquito infection models, may help identify viral determinants of human virulence and mosquito transmission as well as inform vaccine and therapeutic strategies.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Zika virus; antiviral drug discovery; flavivirus; genetic system; mosquito transmission; viral virulence

Mesh：

Substances：

Year:  2016        PMID： 27198478      PMCID： PMC5206987          DOI： 10.1016/j.chom.2016.05.004

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  37 in total

1.  Zika virus. I. Isolations and serological specificity.

Authors:  G W A DICK; S F KITCHEN; A J HADDOW
Journal:  Trans R Soc Trop Med Hyg       Date:  1952-09       Impact factor: 2.184

2.  Development and characterization of a stable luciferase dengue virus for high-throughput screening.

Authors:  Gang Zou; Hao Ying Xu; Min Qing; Qing-Yin Wang; Pei-Yong Shi
Journal:  Antiviral Res       Date:  2011-05-07       Impact factor: 5.970

3.  In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses.

Authors:  Michael K Lo; Pei-Yong Shi; Yen-Liang Chen; Mike Flint; Christina F Spiropoulou
Journal:  Antiviral Res       Date:  2016-03-23       Impact factor: 5.970

4.  Infectious RNA transcribed from stably cloned full-length cDNA of dengue type 4 virus.

Authors:  C J Lai; B T Zhao; H Hori; M Bray
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

5.  Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes.

Authors:  Kelly A Fitzpatrick; Eleanor R Deardorff; Kendra Pesko; Doug E Brackney; Bo Zhang; Edward Bedrick; Pei-Yong Shi; Gregory D Ebel
Journal:  Virology       Date:  2010-08-15       Impact factor: 3.616

6.  Completion of Kunjin virus RNA sequence and recovery of an infectious RNA transcribed from stably cloned full-length cDNA.

Authors:  A A Khromykh; E G Westaway
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

7.  Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence.

Authors:  Konstantin A Tsetsarkin; Scott C Weaver
Journal:  PLoS Pathog       Date:  2011-12-08       Impact factor: 6.823

8.  Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus Flavivirus.

Authors:  Cigdem Alkan; Sonia Zapata; Laurence Bichaud; Grégory Moureau; Philippe Lemey; Andrew E Firth; Tamara S Gritsun; Ernest A Gould; Xavier de Lamballerie; Jérôme Depaquit; Rémi N Charrel
Journal:  J Virol       Date:  2015-09-09       Impact factor: 5.103

9.  Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques.

Authors:  Roland Züst; Hongping Dong; Xiao-Feng Li; David C Chang; Bo Zhang; Thavamalar Balakrishnan; Ying-Xiu Toh; Tao Jiang; Shi-Hua Li; Yong-Qiang Deng; Brett R Ellis; Esther M Ellis; Michael Poidinger; Francesca Zolezzi; Cheng-Feng Qin; Pei-Yong Shi; Katja Fink
Journal:  PLoS Pathog       Date:  2013-08-01       Impact factor: 6.823

10.  Characterization of a Novel Murine Model to Study Zika Virus.

Authors:  Shannan L Rossi; Robert B Tesh; Sasha R Azar; Antonio E Muruato; Kathryn A Hanley; Albert J Auguste; Rose M Langsjoen; Slobodan Paessler; Nikos Vasilakis; Scott C Weaver
Journal:  Am J Trop Med Hyg       Date:  2016-03-28       Impact factor: 2.345
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  143 in total

1.  Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection.

Authors:  Anzhong Li; Miaoge Xue; Zayed Attia; Jingyou Yu; Mijia Lu; Chao Shan; Xueya Liang; Thomas Z Gao; Pei-Yong Shi; Mark E Peeples; Prosper N Boyaka; Shan-Lu Liu; Jianrong Li
Journal:  J Virol       Date:  2020-08-17       Impact factor: 5.103

Review 2.  Animal Models of Zika Virus Infection, Pathogenesis, and Immunity.

Authors:  Thomas E Morrison; Michael S Diamond
Journal:  J Virol       Date:  2017-03-29       Impact factor: 5.103

3.  Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease.

Authors:  Justin M Richner; Brett W Jagger; Chao Shan; Camila R Fontes; Kimberly A Dowd; Bin Cao; Sunny Himansu; Elizabeth A Caine; Bruno T D Nunes; Daniele B A Medeiros; Antonio E Muruato; Bryant M Foreman; Huanle Luo; Tian Wang; Alan D Barrett; Scott C Weaver; Pedro F C Vasconcelos; Shannan L Rossi; Giuseppe Ciaramella; Indira U Mysorekar; Theodore C Pierson; Pei-Yong Shi; Michael S Diamond
Journal:  Cell       Date:  2017-07-13       Impact factor: 41.582

Review 4.  Zika Virus Pathogenesis and Tissue Tropism.

Authors:  Jonathan J Miner; Michael S Diamond
Journal:  Cell Host Microbe       Date:  2017-02-08       Impact factor: 21.023

Review 5.  Animal Models of Zika Virus.

Authors:  Michael P Bradley; Claude M Nagamine
Journal:  Comp Med       Date:  2017-06-01       Impact factor: 0.982

Review 6.  Structure and function of Zika virus NS5 protein: perspectives for drug design.

Authors:  Boxiao Wang; Stephanie Thurmond; Rong Hai; Jikui Song
Journal:  Cell Mol Life Sci       Date:  2018-02-08       Impact factor: 9.261

7.  Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus.

Authors:  Jean A Bernatchez; Zunhua Yang; Michael Coste; Jerry Li; Sungjun Beck; Yan Liu; Alex E Clark; Zhe Zhu; Lucas A Luna; Christal D Sohl; Byron W Purse; Rongshi Li; Jair L Siqueira-Neto
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

8.  Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.

Authors:  Qiming Liang; Zhifei Luo; Jianxiong Zeng; Weiqiang Chen; Suan-Sin Foo; Shin-Ae Lee; Jianning Ge; Su Wang; Steven A Goldman; Berislav V Zlokovic; Zhen Zhao; Jae U Jung
Journal:  Cell Stem Cell       Date:  2016-08-11       Impact factor: 24.633

Review 9.  Did Zika Virus Mutate to Cause Severe Outbreaks?

Authors:  Shannan L Rossi; Gregory D Ebel; Chao Shan; Pei-Yong Shi; Nikos Vasilakis
Journal:  Trends Microbiol       Date:  2018-06-11       Impact factor: 17.079

10.  A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission.

Authors:  Chao Shan; Hongjie Xia; Sherry L Haller; Sasha R Azar; Yang Liu; Jianying Liu; Antonio E Muruato; Rubing Chen; Shannan L Rossi; Maki Wakamiya; Nikos Vasilakis; Rongjuan Pei; Camila R Fontes-Garfias; Sanjay Kumar Singh; Xuping Xie; Scott C Weaver; Pei-Yong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-03       Impact factor: 11.205
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