Literature DB >> 16246031

ABC proteins and antibiotic drug resistance: is it all about transport?

I D Kerr1, E D Reynolds, J H Cove.   

Abstract

The precise mechanism of antibiotic-resistance-conferring ABC (ATP-binding-cassette) proteins (termed NBD2) remains open to debate. Currently, two hypotheses are recognized. In one, the NBD2 proteins are envisaged to act at the ribosome to impair antibiotic access to the target site on the 23 S rRNA. In the other, NBD2 proteins are believed to act as the components of ATP driven efflux pumps by associating with membrane spanning proteins capable of binding and transporting antibiotics. Pertinent data in support of these two hypotheses are discussed in this paper.

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Year:  2005        PMID： 16246031     DOI： 10.1042/BST20051000

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  20 in total

Review 1.  A balancing act: efflux/influx in mycobacterial drug resistance.

Authors:  G E Louw; R M Warren; N C Gey van Pittius; C R E McEvoy; P D Van Helden; T C Victor
Journal:  Antimicrob Agents Chemother       Date:  2009-05-18       Impact factor: 5.191

2.  Resistance Genes Underlying the LSA Phenotype of Staphylococcal Isolates from France.

Authors:  Sophie Tessé; François Trueba; Nicolas Berthet; Chloé Hot; Olivier Chesneau
Journal:  Antimicrob Agents Chemother       Date:  2013-06-24       Impact factor: 5.191

3.  Detailed mutational analysis of Vga(A) interdomain linker: implication for antibiotic resistance specificity and mechanism.

Authors:  Jakub Lenart; Vladimir Vimberg; Ludmila Vesela; Jiri Janata; Gabriela Balikova Novotna
Journal:  Antimicrob Agents Chemother       Date:  2014-12-15       Impact factor: 5.191

Review 4.  Ribosome protection by ABC-F proteins-Molecular mechanism and potential drug design.

Authors:  Rya Ero; Veerendra Kumar; Weixin Su; Yong-Gui Gao
Journal:  Protein Sci       Date:  2019-03-04       Impact factor: 6.725

5.  A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.

Authors:  G Novotna; J Janata
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

6.  Selection of Resistance to Clarithromycin in Mycobacterium abscessus Subspecies.

Authors:  Faiza Mougari; Feriel Bouziane; Flora Crockett; Rachid Nessar; Françoise Chau; Nicolas Veziris; Guillaume Sapriel; Laurent Raskine; Emmanuelle Cambau
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

7.  ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus.

Authors:  Vladimir Vimberg; Jakub Lenart; Jiri Janata; Gabriela Balikova Novotna
Journal:  Antimicrob Agents Chemother       Date:  2015-03-23       Impact factor: 5.191

Review 8.  Resistance to Macrolide Antibiotics in Public Health Pathogens.

Authors:  Corey Fyfe; Trudy H Grossman; Kathy Kerstein; Joyce Sutcliffe
Journal:  Cold Spring Harb Perspect Med       Date:  2016-10-03       Impact factor: 6.915

9.  The repertoire of ABC proteins in Clostridioides difficile.

Authors:  Methinee Pipatthana; Phurt Harnvoravongchai; Pisut Pongchaikul; Somsak Likhitrattanapisal; Matthew Phanchana; Surang Chankhamhaengdecha; Tavan Janvilisri
Journal:  Comput Struct Biotechnol J       Date:  2021-05-08       Impact factor: 7.271

10.  ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection.

Authors:  Liam K R Sharkey; Thomas A Edwards; Alex J O'Neill
Journal:  MBio       Date:  2016-03-22       Impact factor: 7.867
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