Literature DB >> 25801573

ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus.

Vladimir Vimberg1, Jakub Lenart1, Jiri Janata1, Gabriela Balikova Novotna2.   

Abstract

The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion of clpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX is the chaperone component of the ClpXP two-component proteolytic system. Nevertheless, no changes in resistance were observed in a clpP knockout strain expressing msr(A), demonstrating that ClpX affects Msr(A) independently of ClpP.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25801573      PMCID： PMC4432155          DOI： 10.1128/AAC.04367-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  ClpX-mediated remodeling of mu transpososomes: selective unfolding of subunits destabilizes the entire complex.

Authors:  B M Burton; T L Williams; T A Baker
Journal:  Mol Cell       Date:  2001-08       Impact factor: 17.970

2.  Solution structure of the dimeric zinc binding domain of the chaperone ClpX.

Authors:  Logan W Donaldson; Urszula Wojtyra; Walid A Houry
Journal:  J Biol Chem       Date:  2003-10-01       Impact factor: 5.157

3.  Resistance to telithromycin is conferred by msr(A), msrC and msr(D) in Staphylococcus aureus.

Authors:  Elinor D Reynolds; Jonathan H Cove
Journal:  J Antimicrob Chemother       Date:  2005-10-13       Impact factor: 5.790

4.  Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX.

Authors:  Guillaume Thibault; Jovana Yudin; Philip Wong; Vladimir Tsitrin; Remco Sprangers; Rongmin Zhao; Walid A Houry
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-07       Impact factor: 11.205

5.  ClpX inhibits FtsZ assembly in a manner that does not require its ATP hydrolysis-dependent chaperone activity.

Authors:  Daniel P Haeusser; Amy H Lee; Richard B Weart; Petra Anne Levin
Journal:  J Bacteriol       Date:  2009-01-09       Impact factor: 3.490

6.  European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe (1997-2009).

Authors:  Niels Adriaenssens; Samuel Coenen; Ann Versporten; Arno Muller; Girma Minalu; Christel Faes; Vanessa Vankerckhoven; Marc Aerts; Niel Hens; Geert Molenberghs; Herman Goossens
Journal:  J Antimicrob Chemother       Date:  2011-12       Impact factor: 5.790

7.  Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus.

Authors:  Jingyuan Feng; Stephan Michalik; Anders N Varming; Julie H Andersen; Dirk Albrecht; Lotte Jelsbak; Stefanie Krieger; Knut Ohlsen; Michael Hecker; Ulf Gerth; Hanne Ingmer; Dorte Frees
Journal:  J Proteome Res       Date:  2013-01-08       Impact factor: 4.466

8.  Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain.

Authors:  S Cohen; H M Sweeney
Journal:  J Bacteriol       Date:  1970-12       Impact factor: 3.490

9.  Detection of macrolide and disinfectant resistance genes in clinical Staphylococcus aureus and coagulase-negative staphylococci.

Authors:  Tarek Zmantar; Bochra Kouidhi; Hanene Miladi; Amina Bakhrouf
Journal:  BMC Res Notes       Date:  2011-10-27

10.  In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes.

Authors:  G Novotná; J Spízek; J Janata
Journal:  Folia Microbiol (Praha)       Date:  2007       Impact factor: 2.629
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  3 in total

Review 1.  The macrolide antibiotic renaissance.

Authors:  George P Dinos
Journal:  Br J Pharmacol       Date:  2017-08-10       Impact factor: 8.739

Review 2.  Resistance to Macrolide Antibiotics in Public Health Pathogens.

Authors:  Corey Fyfe; Trudy H Grossman; Kathy Kerstein; Joyce Sutcliffe
Journal:  Cold Spring Harb Perspect Med       Date:  2016-10-03       Impact factor: 6.915

3.  Molecular basis of resistance to macrolides, lincosamides and streptogramins in Staphylococcus hominis strains isolated from clinical specimens.

Authors:  Ewa Szczuka; Nicoletta Makowska; Karolina Bosacka; Anna Słotwińska; Adam Kaznowski
Journal:  Folia Microbiol (Praha)       Date:  2015-08-09       Impact factor: 2.099
  3 in total

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