| Literature DB >> 1624370 |
J Ondeyka1, O D Hensens, D Zink, R Ball, R B Lingham, G Bills, A Dombrowski, M Goetz.
Abstract
A novel HIV-1 protease inhibitor, L-696,474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696,474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.Entities:
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Year: 1992 PMID： 1624370 DOI： 10.7164/antibiotics.45.679
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649