Literature DB >> 16243591

Identification of the major metabolites of resveratrol in rat urine by HPLC-MS/MS.

Donggeng Wang1, Taijun Hang, Chunyong Wu, Wenying Liu.   

Abstract

To identify the major metabolites of resveratrol in rat, rat urine samples were pretreated by using solid-phase extraction technique (SPE) with polyamide cartridges. And a LC-MS/MS method with electrospray ionisation (ESI), negative ion mode and collision induced dissociation (CID), was used to elucidate the structures of the major metabolites of resveratrol. According to the results of our experiment, we found that the main metabolites of resveratrol were resveratrol monoglucuronide (M1), dihydroresveratrol monosulfate (M2), resveratrol monosulfate (M3) and dihydroresveratrol (M4).

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Year:  2005        PMID: 16243591     DOI: 10.1016/j.jchromb.2005.09.040

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN: 1570-0232            Impact factor:   3.205


  21 in total

1.  Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs.

Authors:  Miguel Muzzio; Zhihua Huang; Shu-Chieh Hu; William D Johnson; David L McCormick; Izet M Kapetanovic
Journal:  J Pharm Biomed Anal       Date:  2011-10-25       Impact factor: 3.935

2.  Challenges of translating basic research into therapeutics: resveratrol as an example.

Authors:  James M Smoliga; Ole Vang; Joseph A Baur
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-07-11       Impact factor: 6.053

3.  Analytical method development for synthesized conjugated metabolites of trans-resveratrol, and application to pharmacokinetic studies.

Authors:  Otito F Iwuchukwu; Satish Sharan; Daniel J Canney; Swati Nagar
Journal:  J Pharm Biomed Anal       Date:  2011-12-16       Impact factor: 3.935

4.  Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer.

Authors:  Weizhu Zhu; Wenyi Qin; Ke Zhang; George E Rottinghaus; Yin-Chieh Chen; Beth Kliethermes; Edward R Sauter
Journal:  Nutr Cancer       Date:  2012-02-14       Impact factor: 2.900

5.  Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography.

Authors:  David J Boocock; Ketan R Patel; Guy E S Faust; Daniel P Normolle; Timothy H Marczylo; James A Crowell; Dean E Brenner; Tristan D Booth; Andreas Gescher; William P Steward
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2006-11-09       Impact factor: 3.205

6.  Chronic Pancreatitis Associated Acute Respiratory Failure.

Authors:  Murli Manohar; Alok K Verma; Sathisha Upparahalli Venkateshaiah; Nathan L Sanders; Anil Mishra
Journal:  MOJ Immunol       Date:  2017-02-08

Review 7.  Multifaceted approach to resveratrol bioactivity: Focus on antioxidant action, cell signaling and safety.

Authors:  Peter Kovacic; Ratnasamy Somanathan
Journal:  Oxid Med Cell Longev       Date:  2010 Mar-Apr       Impact factor: 6.543

8.  Bioavailability and safety study of resveratrol 500 mg tablets in healthy male and female volunteers.

Authors:  Christakis Sergides; Marinela Chirilă; Luigi Silvestro; Daphne Pitta; Andreas Pittas
Journal:  Exp Ther Med       Date:  2015-11-25       Impact factor: 2.447

9.  Comparative toxicokinetics of Trans-resveratrol and its major metabolites in Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration.

Authors:  Esra Mutlu; Seth T Gibbs; Natalie South; Jessica Pierfelice; Brian Burback; Dori Germolec; Suramya Waidyanatha
Journal:  Toxicol Appl Pharmacol       Date:  2020-03-20       Impact factor: 4.219

10.  Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats.

Authors:  Wei Lan; Liujiao Bian; Xinfeng Zhao; Pu Jia; Xue Meng; Yizhen Wu; Shixiang Wang; Sha Liao; Jie Yu; Xiaohui Zheng
Journal:  J Anal Methods Chem       Date:  2013-03-27       Impact factor: 2.193

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