Literature DB >> 16242340

Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: promising anticancer agents.

Ahmed S Aboraia1, Hamdy M Abdel-Rahman, Nadia M Mahfouz, Mahmoud A El-Gendy.   

Abstract

A series of 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives was synthesized and 13 of them were selected by the National Cancer Institute (NCI) and evaluated for their in vitro anticancer activity. Seven of the investigated compounds, 3i, 3j, 3k, 3o, 3p, 3q, and 3r, displayed high anticancer activity in the primary assay. These compounds have been selected for a full anticancer screening against a 60-cell panel assay where they showed non-selective broad spectrum and promising activity against all cancer cell lines. Compounds 3j and 3k proved to be the active members in this study compared to 5-fluorouracil and cyclophosphamide as reference drugs, respectively. Compounds 3j and 3k were identified as promising lead compounds.

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Year:  2005        PMID： 16242340     DOI： 10.1016/j.bmc.2005.09.053

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  14 in total

1.  1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities.

Authors:  Marwa Ali A Fathi; Amer Ali Abd El-Hafeez; Dalia Abdelhamid; Samar H Abbas; Monica M Montano; Mohamed Abdel-Aziz
Journal:  Bioorg Chem       Date:  2018-11-22       Impact factor: 5.275

2.  5-[1-(3,4-Dichloro-phen-oxy)eth-yl]-1,3,4-oxadiazole-2(3H)-thione hemihydrate.

Authors:  Tashfeen Akhtar; M Khawar Rauf; Shahid Hameed; Xiaoming Lu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-08

3.  Synthesis, characterization and anticancer activity of certain 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino}indolin-2-one derivatives.

Authors:  Rajyalakshmi Gudipati; Rama Narsimha Reddy Anreddy; Sarangapani Manda
Journal:  Saudi Pharm J       Date:  2011-03-11       Impact factor: 4.330

Review 4.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

5.  (S)-N-{1-[5-(4-Chloro-benzyl-sulfanyl)-1,3,4-oxadiazol-2-yl]eth-yl}-4-methyl-benzene-sulfonamide.

Authors:  Tayyaba Syed; Shahid Hameed; Peter G Jones
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-30

6.  (S)-N-[1-(5-Benzyl-sulfan-yl-1,3,4-oxa-diazol-2-yl)-2-phenyl-eth-yl]-4-methyl-benzene-sulfonamide.

Authors:  Tayyaba Syed; Shahid Hameed; Peter G Jones
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-08

7.  Synthesis of Oxadiazolyl, Pyrazolyl and Thiazolyl Derivatives of Thiophene-2-Carboxamide as Antimicrobial and Anti-HCV Agents.

Authors:  Ola H Rizk; Omaima G Shaaban; Abeer E Abdel Wahab
Journal:  Open Med Chem J       Date:  2017-04-28

8.  Synthesis, singlet oxygen photogeneration and DNA photocleavage of porphyrins with nitrogen heterocycle tails.

Authors:  Yun-Man Zheng; Kai Wang; Tian Li; Xiu-Lan Zhang; Zao-Yin Li
Journal:  Molecules       Date:  2011-04-26       Impact factor: 4.411

9.  Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line.

Authors:  Selvaraj Jubie; Palanisamy Dhanabal; Mohammed Afzal Azam; Nithyanantham Muruganantham; Rajagopal Kalirajan; Kannan Elango
Journal:  Lipids Health Dis       Date:  2013-03-28       Impact factor: 3.876

10.  Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids.

Authors:  Mohammad F Hassan; Abdul Rauf; Asif Sherwani; Mohammad Owais
Journal:  Sci Pharm       Date:  2015-06-09
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