Literature DB >> 16242335

Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors.

Nadia Chahboune1, Isabel Barrachina, Inmaculada Royo, Vanessa Romero, Jairo Sáez, José R Tormo, Nuria De Pedro, Ernesto Estornell, M Carmen Zafra-Polo, Fernando Peláez, Diego Cortes.   

Abstract

The antitumoral activity of a series of acetylated bis-tetrahydrofuranic acetogenins with a threo/trans/threo/trans/erythro relative configuration was characterized by four new natural and two semisynthetic, 15,24,30-trioxygenated acetogenins that were found to inhibit mitochondrial complex I enzyme as well as growth of several tumor cell lines. Placement of acetyl groups along the alkyl chain modulated the potency of the bis-tetrahydrofuranic acetogenins and could be important for future utilization of these compounds as chemotherapeutic agents.

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Year:  2005        PMID： 16242335     DOI： 10.1016/j.bmc.2005.09.036

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.

Authors:  Yumin Dai; Liva Harinantenaina; Peggy J Brodie; Martin W Callmander; Richard Randrianaivo; Stephan Rakotonandrasana; Etienne Rakotobe; Vincent E Rasamison; Yongchun Shen; Karen TenDyke; Edward M Suh; David G I Kingston
Journal:  J Nat Prod       Date:  2011-12-02       Impact factor: 4.050

2.  Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I.

Authors:  Nuria de Pedro; Bastien Cautain; Angeles Melguizo; Diego Cortes; Francisca Vicente; Olga Genilloud; Jose R Tormo; Fernando Peláez
Journal:  J Bioenerg Biomembr       Date:  2012-11-21       Impact factor: 2.945

3.  Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway.

Authors:  Nuria de Pedro; Bastien Cautain; Angeles Melguizo; Francisca Vicente; Olga Genilloud; Fernando Peláez; Jose R Tormo
Journal:  J Bioenerg Biomembr       Date:  2012-11-21       Impact factor: 2.945

Review 4.  Mitochondrial peroxiredoxin III is a potential target for cancer therapy.

Authors:  In-Sung Song; Hyoung-Kyu Kim; Seung-Hun Jeong; Sung-Ryul Lee; Nari Kim; Byoung Doo Rhee; Kyung Soo Ko; Jin Han
Journal:  Int J Mol Sci       Date:  2011-10-21       Impact factor: 5.923
  4 in total

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