Literature DB >> 16236508

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.

Timo Weide1, Lars Arve, Heino Prinz, Herbert Waldmann, Horst Kessler.   

Abstract

In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

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Year:  2005        PMID： 16236508     DOI： 10.1016/j.bmcl.2005.09.051

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Silver-Mediated Synthesis of Indolizines via Oxidative C-H functionalization and 5- endo-dig cyclization.

Authors:  Amit N Pandya; James T Fletcher; Eric M Villa; Devendra K Agrawal
Journal:  Tetrahedron Lett       Date:  2014-12-10       Impact factor: 2.415

2.  Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.

Authors:  Rongjun He; Yunpeng Bai; Zhi-Hong Yu; Li Wu; Andrea Michelle Gunawan; Zhong-Yin Zhang
Journal:  Medchemcomm       Date:  2014-10       Impact factor: 3.597

3.  Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor.

Authors:  Rongjun He; Zhihong Yu; Yantao He; Li-Fan Zeng; Jie Xu; Li Wu; Andrea M Gunawan; Lina Wang; Zhong-Xing Jiang; Zhong-Yin Zhang
Journal:  ChemMedChem       Date:  2010-12-03       Impact factor: 3.466

4.  Enantioselective synthesis of α-tetrasubstituted (3-indolizinyl) (diaryl)methanamines via chiral phosphoric acid catalysis.

Authors:  Jialing Zhong; Rihuang Pan; Xufeng Lin
Journal:  RSC Adv       Date:  2022-07-15       Impact factor: 4.036

5.  A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B.

Authors:  Li-Fan Zeng; Jie Xu; Yantao He; Rongjun He; Li Wu; Andrea M Gunawan; Zhong-Yin Zhang
Journal:  ChemMedChem       Date:  2013-04-08       Impact factor: 3.466

6.  Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.

Authors:  Yantao He; Jie Xu; Zhi-Hong Yu; Andrea M Gunawan; Li Wu; Lina Wang; Zhong-Yin Zhang
Journal:  J Med Chem       Date:  2013-01-25       Impact factor: 7.446

7.  Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice.

Authors:  Christoph Grundner; Jeffery S Cox; Tom Alber
Journal:  FEMS Microbiol Lett       Date:  2008-08-22       Impact factor: 2.742

8.  (6S,7S,8R,8aS)-6-Ethyl-perhydro-indolizine-7,8-diol.

Authors:  Lubomír Svorc; Viktor Vrábel; Jozefína Zúžiová; Stefan Marchalín; Jozef Kožíšek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-06-16

9.  Design, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents.

Authors:  Ehsan Faghih-Mirzaei; Mohammad Seifi; Mehdi Abaszadeh; Kamiar Zomorodian; Helia Helali
Journal:  Iran J Pharm Res       Date:  2018       Impact factor: 1.696

10.  Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme.

Authors:  Katharigatta N Venugopala; Sandeep Chandrashekharappa; Pran Kishore Deb; Christophe Tratrat; Melendhran Pillay; Deepak Chopra; Nizar A Al-Shar'i; Wafa Hourani; Lina A Dahabiyeh; Pobitra Borah; Rahul D Nagdeve; Susanta K Nayak; Basavaraj Padmashali; Mohamed A Morsy; Bandar E Aldhubiab; Mahesh Attimarad; Anroop B Nair; Nagaraja Sreeharsha; Michelyne Haroun; Sheena Shashikanth; Viresh Mohanlall; Raghuprasad Mailavaram
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051
  10 in total

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