| Literature DB >> 16236506 |
Clark Sehon1, Kelly McClure, Michael Hack, Magda Morton, Laurent Gomez, Lina Li, Terrance D Barrett, Nigel Shankley, J Guy Breitenbucher.
Abstract
High-throughput screening revealed compound 1 as a potent antagonist of the CCK(1) receptor. Here, we disclose the synthesis of combinatorial libraries by solid-phase synthesis on Kenner 'safety catch' resin. Additive QSAR models were used to determine a lack of consistent additive SAR within the matrix.Entities:
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Year: 2005 PMID： 16236506 DOI： 10.1016/j.bmcl.2005.09.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823