Literature DB >> 16236500

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.

Lei Qiao1, Christian A Baumann, Carl S Crysler, Nisha S Ninan, Marta C Abad, John C Spurlino, Renee L Desjarlais, Jukka Kervinen, Mike P Neeper, Shariff S Bayoumy, Robyn Williams, Ingrid C Deckman, Malini Dasgupta, Rolanda L Reed, Norman D Huebert, Bruce E Tomczuk, Kevin J Moriarty.   

Abstract

The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.

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Year:  2005        PMID： 16236500     DOI： 10.1016/j.bmcl.2005.09.037

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.

Authors:  Fraser F Fleming; Lihua Yao; P C Ravikumar; Lee Funk; Brian C Shook
Journal:  J Med Chem       Date:  2010-08-30       Impact factor: 7.446

2.  3D-QSAR studies of Dipeptidyl peptidase IV inhibitors using a docking based alignment.

Authors:  Raghuvir R S Pissurlenkar; Mushtaque S Shaikh; Evans C Coutinho
Journal:  J Mol Model       Date:  2007-08-04       Impact factor: 1.810

3.  Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitor.

Authors:  Hiroyuki Nojima; Kazuhiko Kanou; Genki Terashi; Mayuko Takeda-Shitaka; Gaku Inoue; Koichiro Atsuda; Chihiro Itoh; Chie Iguchi; Hajime Matsubara
Journal:  BMC Struct Biol       Date:  2016-08-05

4.  Oxidative cyanation of N-aryltetrahydroisoquinoline induced by visible light for the synthesis of α-aminonitrile using potassium thiocyanate as a "CN" agent.

Authors:  Bing Yi; Ning Yan; Niannian Yi; Yanjun Xie; Xiaoyong Wen; Chak-Tong Au; Donghui Lan
Journal:  RSC Adv       Date:  2019-09-19       Impact factor: 4.036

5.  Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assays.

Authors:  Laura Guasch; Maria José Ojeda; Noemí González-Abuín; Esther Sala; Adrià Cereto-Massagué; Miquel Mulero; Cristina Valls; Montserrat Pinent; Anna Ardévol; Santiago Garcia-Vallvé; Gerard Pujadas
Journal:  PLoS One       Date:  2012-09-12       Impact factor: 3.240
  5 in total

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