Literature DB >> 16235913

Facile radical trifluoromethylation of lithium enolates.

Yoshimitsu Itoh1, Koichi Mikami.   

Abstract

[reaction: see text] Highly basic lithium enolates are shown to be applicable to radical trifluoromethylation. The reaction is extremely fast, and the minimum reaction time is approximately 1 s.

Entities:  

Year:  2005        PMID： 16235913     DOI： 10.1021/ol0517574

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Photoredox catalysis: a mild, operationally simple approach to the synthesis of α-trifluoromethyl carbonyl compounds.

Authors:  Phong V Pham; David A Nagib; David W C MacMillan
Journal:  Angew Chem Int Ed Engl       Date:  2011-05-23       Impact factor: 15.336

2.  A simple method for asymmetric trifluoromethylation of N-acyl oxazolidinones via Ru-catalyzed radical addition to zirconium enolates.

Authors:  Aaron T Herrmann; Lindsay L Smith; Armen Zakarian
Journal:  J Am Chem Soc       Date:  2012-04-12       Impact factor: 15.419

3.  Enantioselective alpha-trifluoromethylation of aldehydes via photoredox organocatalysis.

Authors:  David A Nagib; Mark E Scott; David W C MacMillan
Journal:  J Am Chem Soc       Date:  2009-08-12       Impact factor: 15.419
  3 in total

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