Literature DB >> 16235896

Dendrimeric molecular transporters: synthesis and evaluation of tunable polyguanidino dendrimers that facilitate cellular uptake.

Paul A Wender1, Erik Kreider, Erin T Pelkey, Jonathan Rothbard, Christopher L Vandeusen.   

Abstract

[reaction: see text] Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.

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Year:  2005        PMID： 16235896     DOI： 10.1021/ol051496y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  16 in total

1.  Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions.

Authors:  Abhijit Mishra; Ghee Hwee Lai; Nathan W Schmidt; Victor Z Sun; April R Rodriguez; Rong Tong; Li Tang; Jianjun Cheng; Timothy J Deming; Daniel T Kamei; Gerard C L Wong
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-03       Impact factor: 11.205

Review 2.  The design of guanidinium-rich transporters and their internalization mechanisms.

Authors:  Paul A Wender; Wesley C Galliher; Elena A Goun; Lisa R Jones; Thomas H Pillow
Journal:  Adv Drug Deliv Rev       Date:  2007-11-09       Impact factor: 15.470

3.  Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.

Authors:  Paul A Wender
Journal:  Tetrahedron       Date:  2013-06-07       Impact factor: 2.457

4.  Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice.

Authors:  Paul A Wender; Elena A Goun; Lisa R Jones; Thomas H Pillow; Jonathan B Rothbard; Rajesh Shinde; Christopher H Contag
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-11       Impact factor: 11.205

5.  Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery.

Authors:  Colin J McKinlay; Robert M Waymouth; Paul A Wender
Journal:  J Am Chem Soc       Date:  2016-03-07       Impact factor: 15.419

Review 6.  Development of protein mimics for intracellular delivery.

Authors:  Brittany M deRonde; Gregory N Tew
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

Review 7.  Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents.

Authors:  Sarah R MacEwan; Ashutosh Chilkoti
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2012-09-13

8.  Efficient synthesis of fluorescent squaraine rotaxane dendrimers.

Authors:  Shuzhang Xiao; Na Fu; Kaitlin Peckham; Bradley D Smith
Journal:  Org Lett       Date:  2010-01-01       Impact factor: 6.005

9.  Molecular basis for nanoscopic membrane curvature generation from quantum mechanical models and synthetic transporter sequences.

Authors:  Nathan W Schmidt; Michael Lis; Kun Zhao; Ghee Hwee Lai; Anastassia N Alexandrova; Gregory N Tew; Gerard C L Wong
Journal:  J Am Chem Soc       Date:  2012-11-09       Impact factor: 15.419

10.  Oligocarbonate molecular transporters: oligomerization-based syntheses and cell-penetrating studies.

Authors:  Christina B Cooley; Brian M Trantow; Fredrik Nederberg; Matthew K Kiesewetter; James L Hedrick; Robert M Waymouth; Paul A Wender
Journal:  J Am Chem Soc       Date:  2009-11-18       Impact factor: 15.419
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