M Bullarbo1, J Tjugum, E Ekerhovd. 1. Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden. maria.bullarbo@vgregion.se
Abstract
OBJECTIVE: The aim of the study was to investigate the effect of sublingual nitroglycerin for management of retained placenta and to assess possible adverse effects of the treatment. METHOD: Twenty-four women were randomly selected to receive either 1 mg nitroglycerin or placebo tablets sublingually if intravenous oxytocin and controlled umbilical cord traction had failed to expel the placenta. Success rate for delivery of placenta, blood pressure, pulse rate, blood loss, and various side effects were examined. RESULT: All 12 women in the nitroglycerin group had successful delivery of placenta, while removal of placenta was successful in only one of the 12 women in the placebo group. No adverse effects of clinical importance were registered. CONCLUSION:Sublingual nitroglycerin for treatment of retained placenta seems to be effective without causing serious adverse effects. However, the definite clinical value needs to be evaluated in larger series of patients.
RCT Entities:
OBJECTIVE: The aim of the study was to investigate the effect of sublingual nitroglycerin for management of retained placenta and to assess possible adverse effects of the treatment. METHOD: Twenty-four women were randomly selected to receive either 1 mg nitroglycerin or placebo tablets sublingually if intravenous oxytocin and controlled umbilical cord traction had failed to expel the placenta. Success rate for delivery of placenta, blood pressure, pulse rate, blood loss, and various side effects were examined. RESULT: All 12 women in the nitroglycerin group had successful delivery of placenta, while removal of placenta was successful in only one of the 12 women in the placebo group. No adverse effects of clinical importance were registered. CONCLUSION: Sublingual nitroglycerin for treatment of retained placenta seems to be effective without causing serious adverse effects. However, the definite clinical value needs to be evaluated in larger series of patients.
Authors: Fiona C Denison; Kathryn F Carruthers; Jemma Hudson; Gladys McPherson; Graham Scotland; Sheonagh Brook-Smith; Cynthia Clarkson; Mathilde Peace; Jane Brewin; Gin Nie Chua; Nina Hallowell; Jane E Norman; Julia Lawton; John Norrie Journal: Health Technol Assess Date: 2019-12 Impact factor: 4.014
Authors: Fiona C Denison; John Norrie; Julia Lawton; Jane E Norman; Graham Scotland; Gladys C McPherson; Alison McDonald; Mark Forrest; Jemma Hudson; Jane Brewin; Mathilde Peace; Cynthia Clarkson; Sheonagh Brook-Smith; Susan Morrow; Nina Hallowell; Laura Hodges; Kathryn F Carruthers Journal: BMJ Open Date: 2017-09-18 Impact factor: 2.692
Authors: Fiona C Denison; Kathryn F Carruthers; Jemma Hudson; Gladys McPherson; Gin Nie Chua; Mathilde Peace; Jane Brewin; Nina Hallowell; Graham Scotland; Julia Lawton; John Norrie; Jane E Norman Journal: PLoS Med Date: 2019-12-30 Impact factor: 11.069