| Literature DB >> 16225875 |
A V Alessenko1, M A Shupik, A E Bugrova, L B Dudnik, L N Shingarova, A Mikoyan, A F Vanin.
Abstract
We used animal models to study connection between oxidating system and sphingomyelin signaling cascade, because this models are more close related to people disease. Activation of n-sphingomyelinase (n-SMase) in mice liver and brain is coincided in time with increased level of peroxide products (conjugated dienes) after injection of tumor necrosis factor alpha (TNF-alpha). We found that ceramide can induce peroxide oxidation and lead to accumulation of TNF-alpha in animal organs. Nitric oxide (NO) donors (S-nitrosoglutathione and dinitrosyl iron complex) reversibly inhibited activity of n-SMase and decreased level of lipid peroxidation products. This data proposed that both SMase and messengers of oxidative systems could be targets for NO-derived oxidants.Entities:
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Year: 2005 PMID： 16225875 DOI： 10.1016/j.febslet.2005.08.085
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124