OBJECTIVE: To identify the brain regions associated with emotional processing in euthymic bipolar patients. METHODS: The study examined 12 euthymic bipolar patients using functional magnetic resonance imaging (fMRI) while performing an emotional Stroop (eStroop) task. The task comprised emotionally valent and neutral words presented in alternating blocks that was designed to implicitly induce affect. In conjunction with fMRI, galvanic skin responses (GSR) were measured to monitor arousal. RESULTS: Euthymic bipolar patients had diminished activation in response to the affective stimuli in both cortical and subcortical brain regions when compared with healthy subjects. In particular, patients had less activation in the left ventral prefrontal cortex suggesting a potential trait deficit. Patients were slower to react than healthy controls, but did not differ with respect to accuracy. CONCLUSIONS: Euthymic bipolar patients are perhaps constrained in their ability to engage affective processing. Diminished ventral prefrontal cortex activation corroborates previous reports of a potential trait deficit, suggesting that 'all is not well in euthymia', although the effects of medication cannot be overlooked.
OBJECTIVE: To identify the brain regions associated with emotional processing in euthymic bipolarpatients. METHODS: The study examined 12 euthymic bipolarpatients using functional magnetic resonance imaging (fMRI) while performing an emotional Stroop (eStroop) task. The task comprised emotionally valent and neutral words presented in alternating blocks that was designed to implicitly induce affect. In conjunction with fMRI, galvanic skin responses (GSR) were measured to monitor arousal. RESULTS: Euthymic bipolarpatients had diminished activation in response to the affective stimuli in both cortical and subcortical brain regions when compared with healthy subjects. In particular, patients had less activation in the left ventral prefrontal cortex suggesting a potential trait deficit. Patients were slower to react than healthy controls, but did not differ with respect to accuracy. CONCLUSIONS: Euthymic bipolarpatients are perhaps constrained in their ability to engage affective processing. Diminished ventral prefrontal cortex activation corroborates previous reports of a potential trait deficit, suggesting that 'all is not well in euthymia', although the effects of medication cannot be overlooked.
Authors: Mani N Pavuluri; Alessandra M Passarotti; Stephanie A Parnes; Jacklynn M Fitzgerald; John A Sweeney Journal: J Child Adolesc Psychopharmacol Date: 2010-10 Impact factor: 2.576
Authors: Kristen K Ellard; Aishwarya K Gosai; Julia M Felicione; Amy T Peters; Conor V Shea; Louisa G Sylvia; Andrew A Nierenberg; Alik S Widge; Darin D Dougherty; Thilo Deckersbach Journal: Bipolar Disord Date: 2018-11-22 Impact factor: 6.744
Authors: Isabelle E Bauer; Thomas W Frazier; Thomas D Meyer; Eric Youngstrom; Giovana B Zunta-Soares; Jair C Soares Journal: J Child Adolesc Psychopharmacol Date: 2015-10-15 Impact factor: 2.576