Literature DB >> 1622550

Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats.

B G Henriksson1, S Söderström, A J Gower, T Ebendal, B Winblad, A H Mohammed.   

Abstract

Brain nerve growth factor (NGF) was determined in two groups of aged rats: 'good' and 'poor' performers. The animals were selected out of a population of 40 aged rats (26-28 months old) trained in a spatial learning task. Animals performing well in the test had significantly higher NGF in the hippocampus when compared to 'poor' performers. No differences in the levels of NGF were found in the cortex, septum and cerebellum. The results implicate hippocampal NGF in cognitive functioning of aged rats, and suggests that the forebrain cholinergic neuronal atrophy which has been observed in cognitively impaired aged rats may be due to reduced availability of target-derived NGF.

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Year:  1992        PMID： 1622550     DOI： 10.1016/s0166-4328(05)80134-2

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  10 in total

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