Literature DB >> 23604385

Behavioral effects of neurotrophic factor supplementation in aging.

G M Rose.   

Abstract

Neurotrophic factors are now recognized to play important roles in the normal function of the mature central nervous system. This knowledge has motivated experiments to evaluate the potential benefits of administering neurotrophic factors to the aged brain. This article provides a review of studies to date that have determined the behavioral effects of such treatments. Nerve growth factor (NGF) administration appears to reliably enhance learning and memory in aged rats, while glial-derived neurotrophic factor (GDNF) causes some improvement in motor function. Problems associated with neurotrophic factor administration to humans are discussed.

Entities:  

Keywords:  Aging; Behavior; Cognition; Glia-Derived Neurotrophic Factor; Motor; Nerve Growth Factor; Neurotrophin; Therapeutic

Year:  1999        PMID： 23604385      PMCID： PMC3455409          DOI： 10.1007/s11357-999-0001-8

Source DB:  PubMed          Journal:  Age (Omaha)        ISSN： 0161-9152


  75 in total

1.  Age-related differences in adults' macrospatial cognitive processes.

Authors:  K C Kirasic; G L Allen; D Haggerty
Journal:  Exp Aging Res       Date:  1992 Spring-Summer       Impact factor: 1.645

Review 2.  Plasticity in adult and ageing sympathetic neurons.

Authors:  T Cowen; I Gavazzi
Journal:  Prog Neurobiol       Date:  1998-02       Impact factor: 11.685

3.  Memory impaired aged rats: no loss of principal hippocampal and subicular neurons.

Authors:  T Rasmussen; T Schliemann; J C Sørensen; J Zimmer; M J West
Journal:  Neurobiol Aging       Date:  1996 Jan-Feb       Impact factor: 4.673

4.  Selective immunotoxic lesions of basal forebrain cholinergic cells: effects on learning and memory in rats.

Authors:  M G Baxter; D J Bucci; L K Gorman; R G Wiley; M Gallagher
Journal:  Behav Neurosci       Date:  1995-08       Impact factor: 1.912

5.  Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats.

Authors:  D M Armstrong; R Sheffield; G Buzsaki; K S Chen; L B Hersh; B Nearing; F H Gage
Journal:  Neurobiol Aging       Date:  1993 Sep-Oct       Impact factor: 4.673

6.  Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors.

Authors:  C Bäckman; G M Rose; R T Bartus; B J Hoffer; E J Mufson; A C Granholm
Journal:  J Comp Neurol       Date:  1997-10-13       Impact factor: 3.215

7.  Selective lesioning of the basal forebrain cholinergic system by intraventricular 192 IgG-saporin: behavioural, biochemical and stereological studies in the rat.

Authors:  G Leanza; O G Nilsson; R G Wiley; A Björklund
Journal:  Eur J Neurosci       Date:  1995-02-01       Impact factor: 3.386

8.  Human nerve growth factor improves spatial memory in aged but not in young rats.

Authors:  A L Markowska; V E Koliatsos; S J Breckler; D L Price; D S Olton
Journal:  J Neurosci       Date:  1994-08       Impact factor: 6.167

9.  Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration.

Authors:  K S Chen; F H Gage
Journal:  J Neurosci       Date:  1995-04       Impact factor: 6.167

10.  Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.

Authors:  W Fischer; A Sirevaag; S J Wiegand; R M Lindsay; A Björklund
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205
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  1 in total

1.  Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain.

Authors:  Young Il Lee; Yun Gi Kim; Hee Jang Pyeon; Jin Chul Ahn; Sreemathi Logan; Albert Orock; Kyeung Min Joo; Andrea Lőrincz; Ferenc Deák
Journal:  Geroscience       Date:  2019-04-30       Impact factor: 7.713
  1 in total

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