Literature DB >> 16224820

Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.

Johanna Langevin1, Matthew J Morgan, Jean-Baptiste Sibarita, Sandra Aresta, Mala Murthy, Thomas Schwarz, Jacques Camonis, Yohanns Bellaïche.   

Abstract

The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.

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Year:  2005        PMID： 16224820     DOI： 10.1016/j.devcel.2005.07.013

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  127 in total

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9.  The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber.

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Review 10.  Membrane trafficking in morphogenesis and planar polarity.

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