Dunyue Lu1, Asim Mahmood, Michael Chopp. 1. Department of Neurosurgery, Henry Ford Health System, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Abstract
OBJECTIVE: In this review, we analyze progress in the treatment of traumatic brain injury with neurotrophins, growth factors and cell and tissue neurotransplantation. The primary objective of these therapies is to reduce neurologic deficits associated with the trauma by inducing neuroplasticity. These therapies are restorative and not necessarily neuroprotective. MAIN OUTCOME MEASURES: An extensive literature on administration of neurotrophics factors and cell and tissue cerebral transplantation is reviewed. The effects of these therapeutic approaches on brain biochemical, molecular, cellular, and tissue responses are summarized. CONCLUSION: The cumulative data indicate that cell therapy shows substantial promise in the treatment of neural injury.
OBJECTIVE: In this review, we analyze progress in the treatment of traumatic brain injury with neurotrophins, growth factors and cell and tissue neurotransplantation. The primary objective of these therapies is to reduce neurologic deficits associated with the trauma by inducing neuroplasticity. These therapies are restorative and not necessarily neuroprotective. MAIN OUTCOME MEASURES: An extensive literature on administration of neurotrophics factors and cell and tissue cerebral transplantation is reviewed. The effects of these therapeutic approaches on brain biochemical, molecular, cellular, and tissue responses are summarized. CONCLUSION: The cumulative data indicate that cell therapy shows substantial promise in the treatment of neural injury.
Authors: Changsheng Qu; Ye Xiong; Asim Mahmood; David L Kaplan; Anton Goussev; Ruizhuo Ning; Michael Chopp Journal: J Neurosurg Date: 2009-10 Impact factor: 5.115
Authors: Quan Jiang; Changsheng Qu; Michael Chopp; Guang Liang Ding; Siamak P Nejad- Davarani; Joseph A Helpern; Jens H Jensen; Zheng Gang Zhang; Lian Li; Mei Lu; David Kaplan; Jiani Hu; Yimin Shen; Zhifeng Kou; Qingjiang Li; Shiyang Wang; Asim Mahmood Journal: NMR Biomed Date: 2011-03-23 Impact factor: 4.044
Authors: Ye Xiong; Changsheng Qu; Asim Mahmood; Zhongwu Liu; Ruizhuo Ning; Yi Li; David L Kaplan; Timothy Schallert; Michael Chopp Journal: Brain Res Date: 2009-01-30 Impact factor: 3.252