Literature DB >> 16219788

Directional positive selection on an allele of arbitrary dominance.

Kosuke M Teshima1, Molly Przeworski.   

Abstract

Most models of positive directional selection assume codominance of the beneficial allele. We examine the importance of this assumption by implementing a coalescent model of positive directional selection with arbitrary dominance. We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive.

Mesh:

Year:  2005        PMID: 16219788      PMCID: PMC1456198          DOI: 10.1534/genetics.105.044065

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  23 in total

1.  Haldane's sieve and adaptation from the standing genetic variation.

Authors:  H A Orr; A J Betancourt
Journal:  Genetics       Date:  2001-02       Impact factor: 4.562

2.  Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus.

Authors:  M T Hamblin; A Di Rienzo
Journal:  Am J Hum Genet       Date:  2000-04-12       Impact factor: 11.025

3.  Hitchhiking under positive Darwinian selection.

Authors:  J C Fay; C I Wu
Journal:  Genetics       Date:  2000-07       Impact factor: 4.562

4.  Generating samples under a Wright-Fisher neutral model of genetic variation.

Authors:  Richard R Hudson
Journal:  Bioinformatics       Date:  2002-02       Impact factor: 6.937

5.  The signature of positive selection at randomly chosen loci.

Authors:  Molly Przeworski
Journal:  Genetics       Date:  2002-03       Impact factor: 4.562

6.  Extinction time and age of an allele in a large finite population.

Authors:  Onno A van Herwaarden; Nathalie J van der Wal
Journal:  Theor Popul Biol       Date:  2002-05       Impact factor: 1.570

7.  Weak selection revealed by the whole-genome comparison of the X chromosome and autosomes of human and chimpanzee.

Authors:  Jian Lu; Chung-I Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-23       Impact factor: 11.205

8.  The signature of positive selection on standing genetic variation.

Authors:  Molly Przeworski; Graham Coop; Jeffrey D Wall
Journal:  Evolution       Date:  2005-11       Impact factor: 3.694

9.  Human disease genes.

Authors:  G Jimenez-Sanchez; B Childs; D Valle
Journal:  Nature       Date:  2001-02-15       Impact factor: 49.962

10.  A genome-wide departure from the standard neutral model in natural populations of Drosophila.

Authors:  P Andolfatto; M Przeworski
Journal:  Genetics       Date:  2000-09       Impact factor: 4.562

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  40 in total

1.  Patterns of neutral diversity under general models of selective sweeps.

Authors:  Graham Coop; Peter Ralph
Journal:  Genetics       Date:  2012-06-19       Impact factor: 4.562

2.  Selective sweeps for recessive alleles and for other modes of dominance.

Authors:  G Ewing; J Hermisson; P Pfaffelhuber; J Rudolf
Journal:  J Math Biol       Date:  2010-11-13       Impact factor: 2.259

3.  Detecting directional selection in the presence of recent admixture in African-Americans.

Authors:  Kirk E Lohmueller; Carlos D Bustamante; Andrew G Clark
Journal:  Genetics       Date:  2010-12-31       Impact factor: 4.562

4.  Integrating evolutionary and functional approaches to infer adaptation at specific loci.

Authors:  Jay F Storz; Christopher W Wheat
Journal:  Evolution       Date:  2010-09       Impact factor: 3.694

5.  Selective Strolls: Fixation and Extinction in Diploids Are Slower for Weakly Selected Mutations Than for Neutral Ones.

Authors:  Fabrizio Mafessoni; Michael Lachmann
Journal:  Genetics       Date:  2015-10-23       Impact factor: 4.562

6.  How reliable are empirical genomic scans for selective sweeps?

Authors:  Kosuke M Teshima; Graham Coop; Molly Przeworski
Journal:  Genome Res       Date:  2006-05-10       Impact factor: 9.043

Review 7.  Recent and ongoing selection in the human genome.

Authors:  Rasmus Nielsen; Ines Hellmann; Melissa Hubisz; Carlos Bustamante; Andrew G Clark
Journal:  Nat Rev Genet       Date:  2007-11       Impact factor: 53.242

8.  The neutral coalescent process for recent gene duplications and copy-number variants.

Authors:  Kevin R Thornton
Journal:  Genetics       Date:  2007-08-24       Impact factor: 4.562

9.  Simulation of DNA sequence evolution under models of recent directional selection.

Authors:  Yuseob Kim; Thomas Wiehe
Journal:  Brief Bioinform       Date:  2008-12-24       Impact factor: 11.622

10.  Selective sweep at a quantitative trait locus in the presence of background genetic variation.

Authors:  Luis-Miguel Chevin; Frédéric Hospital
Journal:  Genetics       Date:  2008-10-01       Impact factor: 4.562

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