Literature DB >> 1621866

Differential inhibition of fat intake in two strains of rat by the peptide enterostatin.

S Okada1, D A York, G A Bray, J Mei, C Erlanson-Albertsson.   

Abstract

The effect of enterostatin, the amino-terminal pentapeptide of pancreatic procolipase, on food intake was investigated in two strains of rat, the dietary fat-sensitive Osborne-Mendel (OM) rat and the dietary fat-resistant S5B/Pl rat. After an overnight fast, enterostatin inhibited intake of high-fat (HF) but not low-fat (LF) diets in OM rats, but had no effect in S5B/Pl rats. When fed a macronutrient three-choice diet, OM rats selected fat preferentially, whereas S5B/Pl rats selected carbohydrate. Enterostatin specifically inhibited the intake of fat in OM rats but not S5B/Pl rats fed a three-choice macronutrient diet. The activity of pancreatic colipase was increased in S5B/Pl rats on both HF and LF diets compared with OM rats. Pancreatic colipase activities were negatively related to the voluntary intake of fat on three-choice macronutrient diets. The data support the hypothesis that enterostatin may control the intake of dietary fat.

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Year:  1992        PMID： 1621866     DOI： 10.1152/ajpregu.1992.262.6.R1111

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  20 in total

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Journal:  J Gastroenterol       Date:  2002-11       Impact factor: 7.527

Review 2.  Gastrointestinal regulation of food intake.

Authors:  David E Cummings; Joost Overduin
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4.  Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells.

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Journal:  Peptides       Date:  2009-06-27       Impact factor: 3.750

5.  Enterostatin inhibits insulin secretion from isolated perifused rat islets.

Authors:  C Erlanson-Albertsson; B Hering; R G Bretzel; K Federlin
Journal:  Acta Diabetol       Date:  1994-09       Impact factor: 4.280

Review 6.  Heritable variation in food preferences and their contribution to obesity.

Authors:  D R Reed; A A Bachmanov; G K Beauchamp; M G Tordoff; R A Price
Journal:  Behav Genet       Date:  1997-07       Impact factor: 2.805

7.  Altered orosensory sensitivity to oils in CCK-1 receptor deficient rats.

Authors:  T D Swartz; A Hajnal; M Covasa
Journal:  Physiol Behav       Date:  2010-01-12

8.  Procolipase mRNA: tissue localization and effects of diet and adrenalectomy.

Authors:  S Okada; D A York; G A Bray
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

9.  Transcriptional profiling of chromosome 17 quantitative trait Loci for carbohydrate and total calorie intake in a mouse congenic strain reveals candidate genes and pathways.

Authors:  K Ganesh Kumar; Brenda K Smith Richards
Journal:  J Nutrigenet Nutrigenomics       Date:  2008-01-17

10.  CD36 mRNA in the gastrointestinal tract is differentially regulated by dietary fat intake in obesity-prone and obesity-resistant rats.

Authors:  Stefany D Primeaux; H Douglas Braymer; George A Bray
Journal:  Dig Dis Sci       Date:  2012-08-23       Impact factor: 3.199
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