Literature DB >> 16218079

Does insomnia kill?

Barbara Phillips1, David M Mannino.   

Abstract

STUDY
OBJECTIVES: We investigated the prevalence and hazard ratios for insomnia complaints in a large cohort of middle-aged men and women.
DESIGN: The Atherosclerosis Risk in Communities Study is a prospective study of cardiovascular disease. Using multivariate regression analysis, we predicted the likelihood of endorsing the insomnia complaints by age, sex, alcohol intake, smoking, diabetes, heart disease, menopausal status, use of hypnotics, hypertension, depressive symptoms, education level, body mass index, respiratory symptoms, and pulmonary function status. We predicted the hazard ratios (HR) of death at 6.3 +/- 1.1 year by endorsement of insomnia complaints and by hypnotic use controlling for covariates.
SETTING: North American communities. PARTICIPANTS: 13563 participants aged 45 to 69 years at baseline
INTERVENTIONS: None. MEASUREMENTS AND
RESULTS: The prevalence of insomnia complaints in this cohort was 23%. Predictors of insomnia complaints were female sex (odds ratio [OR] 0.56, 95% confidence interval [CI] 0.45-0.70 for men), annual family income below 50,000 dollars (OR 1.23, CI 1.09-1.40), age 40 to 49 years (OR 1.29, CI 1.11-1.50), depressive symptoms (OR 5.05, CI 4.60-5.55), heart disease (OR 1.89, CI 1.67-2.14), severe airflow obstruction (OR 1.61, CI 1.17-2.22), pulmonary symptoms (OR 1.71, CI 1.5-1.95), and restrictive lung disease (OR 1.27, CI 1.10-1.47). After controlling for covariates, insomnia complaints were not associated with an increased risk for death (OR 1.01, CI 0.85-1.21), nor was the use of hypnotics (OR 1.38, CI 0.90-2.13).
CONCLUSIONS: In this cohort, the prevalence of insomnia complaints was 23%. After controlling for confounders, neither insomnia complaints nor hypnotic use predicted increased mortality over 6.3 years.

Entities:  

Mesh:

Year:  2005        PMID: 16218079     DOI: 10.1093/sleep/28.8.965

Source DB:  PubMed          Journal:  Sleep        ISSN: 0161-8105            Impact factor:   5.849


  30 in total

1.  Habitual sleep duration and insomnia and the risk of cardiovascular events and all-cause death: report from a community-based cohort.

Authors:  Kuo-Liong Chien; Pei-Chung Chen; Hsiu-Ching Hsu; Ta-Chen Su; Fung-Chang Sung; Ming-Fong Chen; Yuan-Teh Lee
Journal:  Sleep       Date:  2010-02       Impact factor: 5.849

2.  Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation.

Authors:  Evelyn Mai; Daniel J Buysse
Journal:  Sleep Med Clin       Date:  2008

3.  Association between insomnia symptoms and mortality: a prospective study of U.S. men.

Authors:  Yanping Li; Xuehong Zhang; John W Winkelman; Susan Redline; Frank B Hu; Meir Stampfer; Jing Ma; Xiang Gao
Journal:  Circulation       Date:  2013-11-13       Impact factor: 29.690

4.  Association between hypnotics use and increased mortality: causation or confounding?

Authors:  C Ineke Neutel; Helen L Johansen
Journal:  Eur J Clin Pharmacol       Date:  2015-04-07       Impact factor: 2.953

5.  Heritability and mortality risk of insomnia-related symptoms: a genetic epidemiologic study in a population-based twin cohort.

Authors:  Christer Hublin; Markku Partinen; Markku Koskenvuo; Jaakko Kaprio
Journal:  Sleep       Date:  2011-07-01       Impact factor: 5.849

6.  Association of self-reported sleep and hypertension in non-insomniac elderly subjects.

Authors:  Emilia Sforza; Magali Saint Martin; Jean Claude Barthelemy; Frédéric Roche
Journal:  J Clin Sleep Med       Date:  2014-09-15       Impact factor: 4.062

7.  Sleep loss activates cellular inflammatory signaling.

Authors:  Michael R Irwin; Minge Wang; Denise Ribeiro; Hyong Jin Cho; Richard Olmstead; Elizabeth Crabb Breen; Otoniel Martinez-Maza; Steve Cole
Journal:  Biol Psychiatry       Date:  2008-06-17       Impact factor: 13.382

8.  Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study.

Authors:  Jae-Won Choi; Joonki Lee; Sun Jae Jung; Aesun Shin; Yu Jin Lee
Journal:  J Clin Sleep Med       Date:  2018-10-15       Impact factor: 4.062

9.  Trajectories of cigarette smoking in adulthood predict insomnia among women in late mid-life.

Authors:  David W Brook; Elizabeth Rubenstone; Chenshu Zhang; Judith S Brook
Journal:  Sleep Med       Date:  2012-08-15       Impact factor: 3.492

10.  Insomnia did not predict incident hypertension in older adults in the cardiovascular health study.

Authors:  Barbara Phillips; Petra Bůzková; Paul Enright
Journal:  Sleep       Date:  2009-01       Impact factor: 5.849

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