| Literature DB >> 16216572 |
Abstract
Argonaute (Ago) family proteins are multidomain proteins expressed in prokaryotic and eukaryotic organisms. In eukaryotes, Ago proteins are most well known for their roles in RNA silencing. In prokaryotes, the functions of Ago proteins are unknown, but based on their similarity to eukaryotic Ago proteins, they could be involved in nucleic acid-directed regulatory pathways related to RNA silencing. Recent structural and biochemical studies have shed new light on the function of this family of proteins. These studies reveal how these proteins recognize and cleave RNA and suggest a function for prokaryotic family members.Mesh:
Substances:
Year: 2005 PMID: 16216572 DOI: 10.1016/j.str.2005.08.005
Source DB: PubMed Journal: Structure ISSN: 0969-2126 Impact factor: 5.006