Literature DB >> 16214673

Compounds for the prevention and treatment of noise-induced hearing loss.

Eric D Lynch1, Jonathan Kil.   

Abstract

Noise-induced hearing loss (NIHL) is the leading occupational disease and a major contributor to the development of age-related hearing loss. The pharmacological prevention and treatment of NIHL has been under preclinical investigation for the past 20 years. Promising treatments have now been identified and entered into clinical development. Within the next five years, safe and effective drugs could be approved as the first generation of otoprotectants. This review covers strategies that are under investigation for NIHL. Drugs that effectively prevent and treat NIHL will have a significant impact on medical costs, disability compensation and several issues affecting the quality of life.

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Year:  2005        PMID： 16214673     DOI： 10.1016/S1359-6446(05)03561-0

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  48 in total

1.  Old mice lacking high-affinity nicotine receptors resist acoustic trauma.

Authors:  Haiyan Shen; Zhaoyu Lin; Debin Lei; Josiah Han; Kevin K Ohlemiller; Jianxin Bao
Journal:  Hear Res       Date:  2011-01-25       Impact factor: 3.208

Review 2.  Mechanisms of noise-induced hearing loss indicate multiple methods of prevention.

Authors:  Colleen G Le Prell; Daisuke Yamashita; Shujiro B Minami; Tatsuya Yamasoba; Josef M Miller
Journal:  Hear Res       Date:  2006-12-04       Impact factor: 3.208

3.  Hearing status after an industrial explosion: experience of the AZF explosion, 21 September 2001, France.

Authors:  Stéphanie Rivière; Valérie Schwoebel; Karine Lapierre-Duval; Gérard Warret; Martine Saturnin; Paul Avan; Agnès Job; Thierry Lang
Journal:  Int Arch Occup Environ Health       Date:  2007-08-01       Impact factor: 3.015

4.  Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma.

Authors:  Colleen G Le Prell; Larry F Hughes; Josef M Miller
Journal:  Free Radic Biol Med       Date:  2007-02-20       Impact factor: 7.376

5.  [NO system and anti-oxidants].

Authors:  B Mazurek
Journal:  HNO       Date:  2009-04       Impact factor: 1.284

Review 6.  Otoprotectants: From Research to Clinical Application.

Authors:  Colleen G Le Prell
Journal:  Semin Hear       Date:  2019-04-26

Review 7.  Microsystems technologies for drug delivery to the inner ear.

Authors:  Erin E Leary Pararas; David A Borkholder; Jeffrey T Borenstein
Journal:  Adv Drug Deliv Rev       Date:  2012-02-21       Impact factor: 15.470

Review 8.  Intracochlear drug delivery systems.

Authors:  Jeffrey T Borenstein
Journal:  Expert Opin Drug Deliv       Date:  2011-05-26       Impact factor: 6.648

9.  Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss.

Authors:  Colleen G Le Prell; David F Dolan; David C Bennett; Peter A Boxer
Journal:  Transl Res       Date:  2011-03-09       Impact factor: 7.012

10.  A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity.

Authors:  Carolina Wedemeyer; Lucas G Vattino; Marcelo J Moglie; Jimena Ballestero; Stéphane F Maison; Mariano N Di Guilmi; Julian Taranda; M Charles Liberman; Paul A Fuchs; Eleonora Katz; Ana Belén Elgoyhen
Journal:  J Neurosci       Date:  2018-03-23       Impact factor: 6.167
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