| Literature DB >> 16213790 |
Elly M Hol1, Fred W van Leeuwen, David F Fischer.
Abstract
Ubiquitin-containing cellular inclusions are characteristic of major neurodegenerative diseases and suggest an involvement of the ubiquitin-proteasome system. The frameshifted form of ubiquitin has proved to be a valuable tool for studying the role of the ubiquitin-proteasome system. It is an endogenous reporter for proteasome activity in human pathology but it is also capable of inhibiting proteasomal degradation. Current studies have revealed that the frameshifted form of ubiquitin accumulates in the brains of patients with Alzheimer's disease but not in those with Parkinson's disease.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16213790 DOI： 10.1016/j.molmed.2005.09.001
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951