Literature DB >> 27068270

The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders.

S W French1, A S Mendoza1, Y Peng1.   

Abstract

There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins could prevent AD. We compared the literature on MDBs and AD pathogenesis, which include roles played by p62, ubiquitin UBB +1, HSPs70, 90, 104, FAT10, NEDD8, VCP/97, and the protein quality control mechanisms including the 26s proteasome, the IPOD and JUNQ and autophagosome pathways.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  26S proteasome; Neurofibrillary tangles (NFT); Protein quality control; β amyloid (Aβ)

Mesh：

Substances：

Year:  2016        PMID： 27068270      PMCID： PMC4899135          DOI： 10.1016/j.yexmp.2016.03.010

Source DB:  PubMed          Journal:  Exp Mol Pathol        ISSN： 0014-4800            Impact factor:   3.362


  58 in total

1.  Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin.

Authors:  B A French; F van Leeuwen; N E Riley; Q X Yuan; F Bardag-Gorce; K Gaal; Y H Lue; N Marceau; S W French
Journal:  Exp Mol Pathol       Date:  2001-12       Impact factor: 3.362

2.  Sclerosing hyaline necrosis of the liver in Bloom syndrome.

Authors:  J Wang; M E Cornford; J German; S W French
Journal:  Arch Pathol Lab Med       Date:  1999-04       Impact factor: 5.534

3.  Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.

Authors:  X Zhu; R J Castellani; A Takeda; A Nunomura; C S Atwood; G Perry; M A Smith
Journal:  Mech Ageing Dev       Date:  2001-12       Impact factor: 5.432

4.  Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes.

Authors:  M Ohta; N Marceau; G Perry; V Manetto; P Gambetti; L Autilio-Gambetti; J Metuzals; H Kawahara; M Cadrin; S W French
Journal:  Lab Invest       Date:  1988-12       Impact factor: 5.662

Review 5.  The Mallory body: structure, composition, and pathogenesis.

Authors:  S W French
Journal:  Hepatology       Date:  1981 Jan-Feb       Impact factor: 17.425

6.  Is mallory body formation a preneoplastic change? A study of 181 cases of liver bearing hepatocellular carcinoma and 82 cases of cirrhosis.

Authors:  Y Nakanuma; G Ohta
Journal:  Cancer       Date:  1985-05-15       Impact factor: 6.860

7.  Impaired proteasome function in Alzheimer's disease.

Authors:  J N Keller; K B Hanni; W R Markesbery
Journal:  J Neurochem       Date:  2000-07       Impact factor: 5.372

8.  Proteasome inhibition induces cytokeratin accumulation in vivo.

Authors:  Fawzia Bardag-Gorce; Jennifer Vu; Li Nan; Nora Riley; Jun Li; Samuel W French
Journal:  Exp Mol Pathol       Date:  2004-04       Impact factor: 3.362

9.  Protein aggregation and degradation mechanisms in neurodegenerative diseases.

Authors:  Mari Takalo; Antero Salminen; Hilkka Soininen; Mikko Hiltunen; Annakaisa Haapasalo
Journal:  Am J Neurodegener Dis       Date:  2013-03-08

10.  Localization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer's disease.

Authors:  Romina J G Gentier; Bert M Verheijen; Margherita Zamboni; Maartje M A Stroeken; Denise J H P Hermes; Benno Küsters; Harry W M Steinbusch; David A Hopkins; Fred W Van Leeuwen
Journal:  Front Neuroanat       Date:  2015-03-17       Impact factor: 3.856
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  4 in total

Review 1.  Vimentin's side gig: Regulating cellular proteostasis in mammalian systems.

Authors:  Christopher S Morrow; Darcie L Moore
Journal:  Cytoskeleton (Hoboken)       Date:  2020-11-26

Review 2.  Proteasome and Organs Ischemia-Reperfusion Injury.

Authors:  Joan Oliva
Journal:  Int J Mol Sci       Date:  2017-12-30       Impact factor: 5.923

Review 3.  The Role of FAT10 in Alcoholic Hepatitis Pathogenesis.

Authors:  Yue Jia; Ping Ji; Samuel W French
Journal:  Biomedicines       Date:  2020-07-01

Review 4.  UBA6 and Its Bispecific Pathways for Ubiquitin and FAT10.

Authors:  Fengting Wang; Bo Zhao
Journal:  Int J Mol Sci       Date:  2019-05-07       Impact factor: 5.923
  4 in total

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