Literature DB >> 16213461

Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1.

Niki Kourmouli1, Yuh-man Sun, Sjaak van der Sar, Prim B Singh, Jeremy P Brown.   

Abstract

We developed a model system whereby HP1 can be targeted to pericentric heterochromatin in ES cells lacking Suv(3)9h1/2 histone methyltransferase (HMTase) activities. HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo. Both homo- and hetero-typic interactions between the HP1 isotypes were demonstrated in vivo as were HP1 interactions with the ESET/SETDB1 HMTase and the ATRX chromatin remodelling enzyme. We conclude that HP1 not only "deciphers" the histone code but can also "encode it".

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16213461     DOI： 10.1016/j.bbrc.2005.09.132

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  28 in total

1.  Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice.

Authors:  Yan Jiang; Anouch Matevossian; Yin Guo; Schahram Akbarian
Journal:  Neuropharmacology       Date:  2010-09-30       Impact factor: 5.250

Review 2.  The contradictory definitions of heterochromatin: transcription and silencing.

Authors:  Kathryn L Huisinga; Brent Brower-Toland; Sarah C R Elgin
Journal:  Chromosoma       Date:  2006-02-28       Impact factor: 4.316

3.  Pericentric heterochromatin generated by HP1 protein interaction-defective histone methyltransferase Suv39h1.

Authors:  Daisuke Muramatsu; Prim B Singh; Hiroshi Kimura; Makoto Tachibana; Yoichi Shinkai
Journal:  J Biol Chem       Date:  2013-07-07       Impact factor: 5.157

Review 4.  In praise of mealybugs.

Authors:  Vani Brahmachari; Surbhi Kohli; Parul Gulati
Journal:  J Genet       Date:  2018-06       Impact factor: 1.166

Review 5.  Genetic syndromes caused by mutations in epigenetic genes.

Authors:  María Berdasco; Manel Esteller
Journal:  Hum Genet       Date:  2013-01-31       Impact factor: 4.132

Review 6.  Histone regulation in the CNS: basic principles of epigenetic plasticity.

Authors:  Ian Maze; Kyung-Min Noh; C David Allis
Journal:  Neuropsychopharmacology       Date:  2012-07-25       Impact factor: 7.853

Review 7.  Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals.

Authors:  Prim B Singh
Journal:  J Biosci       Date:  2016-12       Impact factor: 1.826

8.  Role of the epigenetic regulator HP1γ in the control of embryonic stem cell properties.

Authors:  Maïa Caillier; Sandrine Thénot; Violaine Tribollet; Anne-Marie Birot; Jacques Samarut; Anne Mey
Journal:  PLoS One       Date:  2010-11-15       Impact factor: 3.240

Review 9.  The role of genetics in the establishment and maintenance of the epigenome.

Authors:  Covadonga Huidobro; Agustin F Fernandez; Mario F Fraga
Journal:  Cell Mol Life Sci       Date:  2013-03-10       Impact factor: 9.261

10.  The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours.

Authors:  Patricia P Souza; Pamela Völkel; Dave Trinel; Julien Vandamme; Claire Rosnoblet; Laurent Héliot; Pierre-Olivier Angrand
Journal:  BMC Cell Biol       Date:  2009-06-01       Impact factor: 4.241
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.