| Literature DB >> 16213134 |
P K Tsantoulis1, V G Gorgoulis.
Abstract
The E2F family of transcription factors is a central modulator of important cellular events, including cell cycle progression, apoptosis and DNA damage response. The role of E2F family members in various human malignancies is yet unclear and may provide vital clues to the diagnosis, prognosis and therapy of cancer patients. In this review we provide a brief but concise overview of E2F function and its putative role in the most common human tumour types.Entities:
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Year: 2005 PMID： 16213134 DOI： 10.1016/j.ejca.2005.08.005
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162