BACKGROUND: Data on associations of body composition with HIV disease characteristics are limited. OBJECTIVE: We compared sex-specific associations between HIV disease characteristics and body composition in an racially-ethnically diverse cohort of antiretroviral-naive patients. DESIGN: The study was a cross-sectional analysis of participants enrolled in a metabolic substudy of a multicenter trial. Regional fat was measured, and total body fat (TBF) was derived by using the Durnin-Womersley formula (DWF) and bioelectrical impedance analysis (BIA). Body cell mass (BCM) was measured by BIA. RESULTS: Among 422 participants, 22% were women, 60% were African American, and 36% had prior AIDS-defining illnesses. Mean (+/-SD) age was 38.2 +/- 9.6 y, CD4+ count was 215 +/- 184 cells/mm3, and HIV RNA log10 was 5.0 +/- 0.8 copies/mL. On multivariate analysis, women with AIDS-defining illness had significantly (P < 0.005) lower regional body fat and TBF (BIA: -9.5 kg; DWF: -7.3 kg) but nonsignificantly lower BCM (-1.3 kg) than did women without such illnesses, whereas men with AIDS-defining illness had significantly (P < 0.005) lower BCM (-1.7 kg) but nonsignificantly lower TBF (BIA: -1.3 kg; DWF: -1.83 kg) than did men without such illnesses (P < 0.05 for sex differences in TBF). Significant negative associations of HIV RNA with BCM (-0.9 kg/log RNA; P = 0.03), TBF by BIA (-1.4 kg/log RNA; P = 0.05) and by DWF (-1.6 kg/log RNA; P = 0.01), and regional fat were observed in men only. CONCLUSIONS: The effect of prior AIDS illness on body fat differed significantly between the sexes: women with prior AIDS-defining illness had significantly less fat than did women without such illnesses. An independent effect of HIV viremia on BCM and fat was seen in men. These distinctions may be due to inherent biological differences between the sexes.
BACKGROUND: Data on associations of body composition with HIV disease characteristics are limited. OBJECTIVE: We compared sex-specific associations between HIV disease characteristics and body composition in an racially-ethnically diverse cohort of antiretroviral-naive patients. DESIGN: The study was a cross-sectional analysis of participants enrolled in a metabolic substudy of a multicenter trial. Regional fat was measured, and total body fat (TBF) was derived by using the Durnin-Womersley formula (DWF) and bioelectrical impedance analysis (BIA). Body cell mass (BCM) was measured by BIA. RESULTS: Among 422 participants, 22% were women, 60% were African American, and 36% had prior AIDS-defining illnesses. Mean (+/-SD) age was 38.2 +/- 9.6 y, CD4+ count was 215 +/- 184 cells/mm3, and HIV RNA log10 was 5.0 +/- 0.8 copies/mL. On multivariate analysis, women with AIDS-defining illness had significantly (P < 0.005) lower regional body fat and TBF (BIA: -9.5 kg; DWF: -7.3 kg) but nonsignificantly lower BCM (-1.3 kg) than did women without such illnesses, whereas men with AIDS-defining illness had significantly (P < 0.005) lower BCM (-1.7 kg) but nonsignificantly lower TBF (BIA: -1.3 kg; DWF: -1.83 kg) than did men without such illnesses (P < 0.05 for sex differences in TBF). Significant negative associations of HIV RNA with BCM (-0.9 kg/log RNA; P = 0.03), TBF by BIA (-1.4 kg/log RNA; P = 0.05) and by DWF (-1.6 kg/log RNA; P = 0.01), and regional fat were observed in men only. CONCLUSIONS: The effect of prior AIDS illness on body fat differed significantly between the sexes: women with prior AIDS-defining illness had significantly less fat than did women without such illnesses. An independent effect of HIV viremia on BCM and fat was seen in men. These distinctions may be due to inherent biological differences between the sexes.
Authors: S S Martinez; A Campa; H Bussmann; S Moyo; J Makhema; F G Huffman; O D Williams; M Essex; R Marlink; M K Baum Journal: Br J Nutr Date: 2016-04-18 Impact factor: 3.718
Authors: Neeti Agarwal; Dinakar Iyer; Sanjeet G Patel; Rajagopal V Sekhar; Terry M Phillips; Ulrich Schubert; Toni Oplt; Eric D Buras; Susan L Samson; Jacob Couturier; Dorothy E Lewis; Maria C Rodriguez-Barradas; Farook Jahoor; Tomoshige Kino; Jeffrey B Kopp; Ashok Balasubramanyam Journal: Sci Transl Med Date: 2013-11-27 Impact factor: 17.956
Authors: Shashi Shrivastav; Tomoshige Kino; Tshaka Cunningham; Takamasa Ichijo; Ulrich Schubert; Peter Heinklein; George P Chrousos; Jeffrey B Kopp Journal: Mol Endocrinol Date: 2007-10-11
Authors: M F Olsen; P Kæstel; M Tesfaye; A Abdissa; D Yilma; T Girma; C Mølgaard; D Faurholt-Jepsen; D L Christensen; S Brage; Å B Andersen; H Friis Journal: Epidemiol Infect Date: 2014-06-24 Impact factor: 4.434
Authors: Henrik Friis; Nyagosya Range; John Changalucha; George Praygod; Kidola Jeremiah; Daniel Faurholt-Jepsen; Henrik Krarup; Christian Mølgaard; Åse Bengaard Andersen Journal: PLoS One Date: 2013-12-06 Impact factor: 3.240