| Literature DB >> 16202581 |
Helen L Birch1, George M Buckley, Natasha Davies, Hazel J Dyke, Elizabeth J Frost, Philip J Gilbert, Duncan R Hannah, Alan F Haughan, Michael J Madigan, Trevor Morgan, William R Pitt, Andrew J Ratcliffe, Nicholas C Ray, Marianna D Richard, Andrew Sharpe, Alicia J Taylor, Justine M Whitworth, Sophie C Williams.
Abstract
The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II).Entities:
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Year: 2005 PMID： 16202581 DOI： 10.1016/j.bmcl.2005.06.108
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823