BACKGROUND: Linkage studies have confirmed that chromosome 1q23.3 is a susceptibility locus for schizophrenia. It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families. A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia. METHODS: We attempted replication using eight markers from the Canadian study in a UK based sample of 450 cases and 450 supernormal controls. RESULTS: We found no evidence for allelic or haplotypic association with schizophrenia for any of the markers found to be associated in the Canadian sample. CONCLUSIONS: The negative results might reflect genetic heterogeneity between the Canadian, Chinese and UK samples or be due to methodological problems. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.
BACKGROUND: Linkage studies have confirmed that chromosome 1q23.3 is a susceptibility locus for schizophrenia. It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families. A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia. METHODS: We attempted replication using eight markers from the Canadian study in a UK based sample of 450 cases and 450 supernormal controls. RESULTS: We found no evidence for allelic or haplotypic association with schizophrenia for any of the markers found to be associated in the Canadian sample. CONCLUSIONS: The negative results might reflect genetic heterogeneity between the Canadian, Chinese and UK samples or be due to methodological problems. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.
Authors: Khalid Choudhury; Andrew McQuillin; Vinay Puri; Jonathan Pimm; Susmita Datta; Srinivasa Thirumalai; Robert Krasucki; Jacob Lawrence; Nicholas J Bass; Digby Quested; Caroline Crombie; Gillian Fraser; Nicholas Walker; Haitham Nadeem; Sophie Johnson; David Curtis; David St Clair; Hugh M D Gurling Journal: Am J Hum Genet Date: 2007-03-01 Impact factor: 11.025
Authors: Barbara Kremeyer; Jenny García; Hanna Kymäläinen; Naomi Wratten; Gabriel Restrepo; Carlos Palacio; Ana Lucía Miranda; Carlos López; Margarita Restrepo; Gabriel Bedoya; Linda M Brzustowicz; Jorge Ospina-Duque; María Patricia Arbeláez; Andrés Ruiz-Linares Journal: Hum Hered Date: 2008-12-15 Impact factor: 0.444
Authors: Richard Delorme; Catalina Betancur; Isabelle Scheid; Henrik Anckarsäter; Pauline Chaste; Stéphane Jamain; Franck Schuroff; Gudrun Nygren; Evelyn Herbrecht; Anne Dumaine; Marie Christine Mouren; Maria Råstam; Marion Leboyer; Christopher Gillberg; Thomas Bourgeron Journal: BMC Med Genet Date: 2010-07-05 Impact factor: 2.103
Authors: Daniel B Campbell; Leslie A Lange; Tara Skelly; Jeffrey Lieberman; Pat Levitt; Patrick F Sullivan Journal: Schizophr Res Date: 2008-02-11 Impact factor: 4.939