Literature DB >> 16200194

The survival kinases Akt and Pim as potential pharmacological targets.

Ravi Amaravadi1, Craig B Thompson.   

Abstract

The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.

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Year:  2005        PMID： 16200194      PMCID： PMC1236693          DOI： 10.1172/JCI26273

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  84 in total

1.  Direct control of the Forkhead transcription factor AFX by protein kinase B.

Authors:  G J Kops; N D de Ruiter; A M De Vries-Smits; D R Powell; J L Bos; B M Burgering
Journal:  Nature       Date:  1999-04-15       Impact factor: 49.962

2.  Integrin-linked kinase expression increases with prostate tumor grade.

Authors:  J R Graff; J A Deddens; B W Konicek; B M Colligan; B M Hurst; H W Carter; J H Carter
Journal:  Clin Cancer Res       Date:  2001-07       Impact factor: 12.531

3.  Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

Authors:  S R Datta; H Dudek; X Tao; S Masters; H Fu; Y Gotoh; M E Greenberg
Journal:  Cell       Date:  1997-10-17       Impact factor: 41.582

4.  Induction of NF-kappaB by the Akt/PKB kinase.

Authors:  L P Kane; V S Shapiro; D Stokoe; A Weiss
Journal:  Curr Biol       Date:  1999-06-03       Impact factor: 10.834

5.  Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades.

Authors:  J Deprez; D Vertommen; D R Alessi; L Hue; M H Rider
Journal:  J Biol Chem       Date:  1997-07-11       Impact factor: 5.157

6.  Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3.

Authors:  S Masure; B Haefner; J J Wesselink; E Hoefnagel; E Mortier; P Verhasselt; A Tuytelaars; R Gordon; A Richardson
Journal:  Eur J Biochem       Date:  1999-10-01

7.  Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.

Authors:  Ildiko Bock-Marquette; Ankur Saxena; Michael D White; J Michael Dimaio; Deepak Srivastava
Journal:  Nature       Date:  2004-11-25       Impact factor: 49.962

8.  A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer.

Authors:  Lynn Van Ummersen; Kim Binger; Jennifer Volkman; Rebecca Marnocha; Kendra Tutsch; Jill Kolesar; Rhoda Arzoomanian; Dona Alberti; George Wilding
Journal:  Clin Cancer Res       Date:  2004-11-15       Impact factor: 12.531

9.  Regulation of cell death protease caspase-9 by phosphorylation.

Authors:  M H Cardone; N Roy; H R Stennicke; G S Salvesen; T F Franke; E Stanbridge; S Frisch; J C Reed
Journal:  Science       Date:  1998-11-13       Impact factor: 47.728

10.  Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.

Authors:  Peter S Hammerman; Casey J Fox; Ryan M Cinalli; Anne Xu; John D Wagner; Tullia Lindsten; Craig B Thompson
Journal:  Cancer Res       Date:  2004-11-15       Impact factor: 12.701
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  145 in total

1.  PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha.

Authors:  Iris Eke; Ulrike Koch; Stephanie Hehlgans; Veit Sandfort; Fabio Stanchi; Daniel Zips; Michael Baumann; Anna Shevchenko; Christian Pilarsky; Michael Haase; Gustavo B Baretton; Véronique Calleja; Banafshé Larijani; Reinhard Fässler; Nils Cordes
Journal:  J Clin Invest       Date:  2010-06-07       Impact factor: 14.808

2.  Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation.

Authors:  Yoo Seob Shin; Katsuyuki Takeda; Yoshiki Shiraishi; Yi Jia; Meiqin Wang; Leila Jackson; A Dale Wright; Laura Carter; John Robinson; Erik Hicken; Erwin W Gelfand
Journal:  Am J Respir Cell Mol Biol       Date:  2011-11-10       Impact factor: 6.914

3.  Regulation of Skp2 levels by the Pim-1 protein kinase.

Authors:  Bo Cen; Sandeep Mahajan; Marina Zemskova; Zanna Beharry; Ying-Wei Lin; Scott D Cramer; Michael B Lilly; Andrew S Kraft
Journal:  J Biol Chem       Date:  2010-07-27       Impact factor: 5.157

Review 4.  Development of phosphoinositide-3 kinase pathway inhibitors for advanced cancer.

Authors:  James M Cleary; Geoffrey I Shapiro
Journal:  Curr Oncol Rep       Date:  2010-03       Impact factor: 5.075

Review 5.  For better or for worse: the role of Pim oncogenes in tumorigenesis.

Authors:  Martijn C Nawijn; Andrej Alendar; Anton Berns
Journal:  Nat Rev Cancer       Date:  2010-12-09       Impact factor: 60.716

6.  Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.

Authors:  Hai-Tong Fang; Bo Zhang; Xiao-Fen Pan; Li Gao; Tao Zhen; Hong-Xia Zhao; Liang Ma; Jun Xie; Zi Liu; Xian-Jun Yu; Xin Cheng; Ting-Ting Feng; Feng-Xiang Zhang; Yong Yang; Zhong-Guo Hu; Guo-Qing Sheng; Yong-Long Chen; Sai-Juan Chen; Zhu Chen; Guang-Biao Zhou
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-27       Impact factor: 11.205

Review 7.  PIM1: a promising target in patients with triple-negative breast cancer.

Authors:  Wen Zhao; RuiYue Qiu; Pan Li; Jin Yang
Journal:  Med Oncol       Date:  2017-07-18       Impact factor: 3.064

8.  Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment.

Authors:  Linhua Jin; Yoko Tabe; Hongbo Lu; Gautam Borthakur; Takashi Miida; Hagop Kantarjian; Michael Andreeff; Marina Konopleva
Journal:  Cancer Lett       Date:  2012-10-02       Impact factor: 8.679

9.  Integrated signaling in developing lymphocytes: the role of DNA damage responses.

Authors:  Jeffrey J Bednarski; Barry P Sleckman
Journal:  Cell Cycle       Date:  2012-10-03       Impact factor: 4.534

10.  Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression.

Authors:  Hua-Chuan Zheng; Koichi Tsuneyama; Hiroyuki Takahashi; Shigeharu Miwa; Toshiro Sugiyama; Boryana Konstantinova Popivanova; Chifumi Fujii; Kazuhiro Nomoto; Naofumi Mukaida; Yasuo Takano
Journal:  J Cancer Res Clin Oncol       Date:  2007-09-18       Impact factor: 4.553
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