BACKGROUND: Studies have shown increased bilateral activation in the prefrontal cortex when normal individuals lie, but there have been no structural imaging studies of deceitful individuals. AIMS: To assess whether deceitful individuals show structural abnormalities in prefrontal grey and white matter volume. METHOD: Prefrontal grey and white matter volumes were assessed using structural magnetic resonance imaging in 12 individuals who pathologically lie, cheat and deceive ('liars'),16 antisocial controls and 21 normal controls. RESULTS: Liars showed a 22-26% increase in prefrontal white matter and a 36-42% reduction in prefrontal grey/white ratios compared with both antisocial controls and normal controls. CONCLUSIONS: These findings provide the first evidence of a structural brain deficitinliars, they implicate the prefrontal cortex as an important (but not sole) component in the neural circuitry underlying lying and provide an initial neurobiological correlate of a deceitful personality.
BACKGROUND: Studies have shown increased bilateral activation in the prefrontal cortex when normal individuals lie, but there have been no structural imaging studies of deceitful individuals. AIMS: To assess whether deceitful individuals show structural abnormalities in prefrontal grey and white matter volume. METHOD: Prefrontal grey and white matter volumes were assessed using structural magnetic resonance imaging in 12 individuals who pathologically lie, cheat and deceive ('liars'),16 antisocial controls and 21 normal controls. RESULTS: Liars showed a 22-26% increase in prefrontal white matter and a 36-42% reduction in prefrontal grey/white ratios compared with both antisocial controls and normal controls. CONCLUSIONS: These findings provide the first evidence of a structural brain deficitinliars, they implicate the prefrontal cortex as an important (but not sole) component in the neural circuitry underlying lying and provide an initial neurobiological correlate of a deceitful personality.
Authors: Yaling Yang; Adrian Raine; Katherine L Narr; Todd Lencz; Lori LaCasse; Patrick Colletti; Arthur W Toga Journal: Br J Psychiatry Date: 2007-02 Impact factor: 9.319
Authors: Veena M Narayan; Katherine L Narr; Veena Kumari; Roger P Woods; Paul M Thompson; Arthur W Toga; Tonmoy Sharma Journal: Am J Psychiatry Date: 2007-09 Impact factor: 18.112
Authors: Kim M Cecil; Christopher J Brubaker; Caleb M Adler; Kim N Dietrich; Mekibib Altaye; John C Egelhoff; Stephanie Wessel; Ilayaraja Elangovan; Richard Hornung; Kelly Jarvis; Bruce P Lanphear Journal: PLoS Med Date: 2008-05-27 Impact factor: 11.069