Literature DB >> 16199588

The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant staphylococci, including methicillin-resistant Staphylococcus aureus.

S O'Flaherty1, A Coffey, W Meaney, G F Fitzgerald, R P Ross.   

Abstract

This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis. Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus. LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.

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Year:  2005        PMID： 16199588      PMCID： PMC1251611          DOI： 10.1128/JB.187.20.7161-7164.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

1.  Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity.

Authors:  W W Navarre; H Ton-That; K F Faull; O Schneewind
Journal:  J Biol Chem       Date:  1999-05-28       Impact factor: 5.157

2.  Production of enterolysin A by a raw milk enterococcal isolate exhibiting multiple virulence factors.

Authors:  Rita M Hickey; Denis P Twomey; R Paul Ross; Colin Hill
Journal:  Microbiology       Date:  2003-03       Impact factor: 2.777

3.  Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains.

Authors:  J M Loeffler; V A Fischetti
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

4.  Virolysin: a virus-induced lysin from staphylococcal phage lysates.

Authors:  D J RALSTON; B S BAER; M LIEBERMAN; A P KRUEGER
Journal:  Proc Soc Exp Biol Med       Date:  1955-08

5.  Potential of the polyvalent anti-Staphylococcus bacteriophage K for control of antibiotic-resistant staphylococci from hospitals.

Authors:  S O'Flaherty; R P Ross; W Meaney; G F Fitzgerald; M F Elbreki; A Coffey
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

6.  Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme.

Authors:  D Nelson; L Loomis; V A Fischetti
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

7.  Molecular analysis of lytic genes of bacteriophage 80 alpha of Staphylococcus aureus.

Authors:  J Bon; N Mani; R K Jayaswal
Journal:  Can J Microbiol       Date:  1997-07       Impact factor: 2.419

8.  Evidence for a holin-like protein gene fully embedded out of frame in the endolysin gene of Staphylococcus aureus bacteriophage 187.

Authors:  M J Loessner; S Gaeng; S Scherer
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

9.  Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin.

Authors:  P G de Ruyter; O P Kuipers; W M de Vos
Journal:  Appl Environ Microbiol       Date:  1996-10       Impact factor: 4.792

10.  A bacteriolytic agent that detects and kills Bacillus anthracis.

Authors:  Raymond Schuch; Daniel Nelson; Vincent A Fischetti
Journal:  Nature       Date:  2002-08-22       Impact factor: 49.962
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  83 in total

Review 1.  Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens.

Authors:  Vincent A Fischetti
Journal:  Int J Med Microbiol       Date:  2010-05-10       Impact factor: 3.473

2.  Lytic activity of recombinant bacteriophage phi11 and phi12 endolysins on whole cells and biofilms of Staphylococcus aureus.

Authors:  Peter Sass; Gabriele Bierbaum
Journal:  Appl Environ Microbiol       Date:  2006-11-03       Impact factor: 4.792

3.  Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci.

Authors:  Marianne Horgan; Gary O'Flynn; Jennifer Garry; Jakki Cooney; Aidan Coffey; Gerald F Fitzgerald; R Paul Ross; Olivia McAuliffe
Journal:  Appl Environ Microbiol       Date:  2008-12-01       Impact factor: 4.792

4.  LysGH15, a novel bacteriophage lysin, protects a murine bacteremia model efficiently against lethal methicillin-resistant Staphylococcus aureus infection.

Authors:  Jingmin Gu; Wei Xu; Liancheng Lei; Jing Huang; Xin Feng; Changjiang Sun; Chongtao Du; Jing Zuo; Yang Li; Taofeng Du; Linxi Li; Wenyu Han
Journal:  J Clin Microbiol       Date:  2010-11-03       Impact factor: 5.948

5.  Identification of Peptidoglycan Hydrolase Constructs with Synergistic Staphylolytic Activity in Cow's Milk.

Authors:  Carolin T Verbree; Steven M Dätwyler; Susanne Meile; Fritz Eichenseher; David M Donovan; Martin J Loessner; Mathias Schmelcher
Journal:  Appl Environ Microbiol       Date:  2017-03-17       Impact factor: 4.792

6.  Lysostaphin Lysibody Leads to Effective Opsonization and Killing of Methicillin-Resistant Staphylococcus aureus in a Murine Model.

Authors:  Assaf Raz; Anna Serrano; Maneesha Thaker; Tricia Alston; Vincent A Fischetti
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

Review 7.  Bacteriophage endolysins as novel antimicrobials.

Authors:  Mathias Schmelcher; David M Donovan; Martin J Loessner
Journal:  Future Microbiol       Date:  2012-10       Impact factor: 3.165

8.  Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus.

Authors:  Anu Daniel; Chad Euler; Mattias Collin; Peter Chahales; Kenneth J Gorelick; Vincent A Fischetti
Journal:  Antimicrob Agents Chemother       Date:  2010-01-19       Impact factor: 5.191

9.  Phage Therapy - Everything Old is New Again.

Authors:  Andrew M Kropinski
Journal:  Can J Infect Dis Med Microbiol       Date:  2006-09       Impact factor: 2.471

Review 10.  Bacteriophage lysins as effective antibacterials.

Authors:  Vincent A Fischetti
Journal:  Curr Opin Microbiol       Date:  2008-10-14       Impact factor: 7.934
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