OBJECTIVE: High body mass index (BMI) is associated with mortality in the general population, whereas obesity is suggested to confer a survival advantage in hemodialysis (HD) patients. However, underlying mechanisms are yet to be elucidated. We examined the cross-sectional association of BMI with inflammatory and nutritional markers and atherosclerosis in HD patients. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: One hundred and nine maintenance HD patients in the Hacettepe University Hospital Haemodialysis Unit were studied. METHODS: Data on demographics, comorbidity, and anthropometry were obtained by patient interviews. Atherosclerosis was assessed by B-mode Doppler ultrasonography on common carotid artery. Serum markers of inflammation, nutrition, and lipid metabolism, including C-reactive protein (CRP), albumin, prealbumin, homocysteine and lipoproteins, were measured by standard methods. MAIN OUTCOME MEASURE: Distribution of inflammatory and nutritional markers and prevalence of atherosclerosis in underweight, normal, overweight, and obese HD patients. RESULTS: CRP levels were significantly higher in obese and underweight HD patients compared with normal and overweight patients (P < .05). The prevalence of atherosclerosis was significantly higher in underweight and obese patients (54.5% and 50%) compared with normal and overweight patients (25.7% and 33%) (P < .05). CONCLUSIONS: In the present study, obesity is associated with inflammation and atherosclerosis. An obesity-related survival advantage should be modified by other factors such as race, comorbid conditions, body composition, and nutritional status.
OBJECTIVE: High body mass index (BMI) is associated with mortality in the general population, whereas obesity is suggested to confer a survival advantage in hemodialysis (HD) patients. However, underlying mechanisms are yet to be elucidated. We examined the cross-sectional association of BMI with inflammatory and nutritional markers and atherosclerosis in HDpatients. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: One hundred and nine maintenance HDpatients in the Hacettepe University Hospital Haemodialysis Unit were studied. METHODS: Data on demographics, comorbidity, and anthropometry were obtained by patient interviews. Atherosclerosis was assessed by B-mode Doppler ultrasonography on common carotid artery. Serum markers of inflammation, nutrition, and lipid metabolism, including C-reactive protein (CRP), albumin, prealbumin, homocysteine and lipoproteins, were measured by standard methods. MAIN OUTCOME MEASURE: Distribution of inflammatory and nutritional markers and prevalence of atherosclerosis in underweight, normal, overweight, and obeseHDpatients. RESULTS:CRP levels were significantly higher in obese and underweight HDpatients compared with normal and overweight patients (P < .05). The prevalence of atherosclerosis was significantly higher in underweight and obesepatients (54.5% and 50%) compared with normal and overweight patients (25.7% and 33%) (P < .05). CONCLUSIONS: In the present study, obesity is associated with inflammation and atherosclerosis. An obesity-related survival advantage should be modified by other factors such as race, comorbid conditions, body composition, and nutritional status.
Authors: Holly Kramer; Katherine R Tuttle; David Leehey; Amy Luke; Ramon Durazo-Arvizu; David Shoham; Richard Cooper; Srinvisan Beddhu Journal: Am J Kidney Dis Date: 2009-01 Impact factor: 8.860
Authors: Kamil Borkowski; John W Newman; Nima Aghaeepour; Jonathan A Mayo; Ivana Blazenović; Oliver Fiehn; David K Stevenson; Gary M Shaw; Suzan L Carmichael Journal: PLoS One Date: 2020-11-17 Impact factor: 3.240