| Literature DB >> 16198625 |
Saleta Sierra1, Bernd Kupfer, Rolf Kaiser.
Abstract
Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The understanding of HIV-1 pathogenesis is essential to develop and maintain antiretroviral treatment and vaccination. Since the first isolation of HIV-1 in cell culture, thousands of publications dealing with HIV and/or AIDS per year were released. In this review we give a basic overview of the virology of HIV-1 including the functions of the different HIV-1 proteins required for effective viral replication. Moreover, we summarize the interactive processes between HIV-1 and its target cells. Finally, the HIV-1 specific immune response and the current status of antiretroviral therapy are briefly described in this review.Entities:
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Year: 2005 PMID： 16198625 DOI： 10.1016/j.jcv.2005.09.004
Source DB: PubMed Journal: J Clin Virol ISSN： 1386-6532 Impact factor: 3.168