Literature DB >> 16193124

Chemical optimization of artificial metalloenzymes based on the biotin-avidin technology: (S)-selective and solvent-tolerant hydrogenation catalysts via the introduction of chiral amino acid spacers.

Myriem Skander1, Christophe Malan, Anita Ivanova, Thomas R Ward.   

Abstract

Incorporation of biotinylated-[rhodium(diphosphine)]+ complexes, with enantiopure amino acid spacers, in streptavidin affords solvent-tolerant and selective artificial metalloenzymes: up to 91% ee (S) in the hydrogenation of N-protected dehydroamino acids.

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Year:  2005        PMID： 16193124     DOI： 10.1039/b509015f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  Protein design: toward functional metalloenzymes.

Authors:  Fangting Yu; Virginia M Cangelosi; Melissa L Zastrow; Matteo Tegoni; Jefferson S Plegaria; Alison G Tebo; Catherine S Mocny; Leela Ruckthong; Hira Qayyum; Vincent L Pecoraro
Journal:  Chem Rev       Date:  2014-03-24       Impact factor: 60.622

2.  Counter propagation artificial neural networks modeling of an enantioselectivity of artificial metalloenzymes.

Authors:  Sylwester Mazurek; Thomas R Ward; Marjana Novic
Journal:  Mol Divers       Date:  2008-03-04       Impact factor: 2.943
  2 in total

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