Literature DB >> 16189124

Penetration of piperacillin and tazobactam into inflamed soft tissue of patients with diabetic foot infection.

F J Legat1, R Krause, P Zenahlik, C Hoffmann, S Scholz, W Salmhofer, J Tscherpel, T Tscherpel, H Kerl, P Dittrich.   

Abstract

We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue.

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Year:  2005        PMID： 16189124      PMCID： PMC1251535          DOI： 10.1128/AAC.49.10.4368-4371.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

Review 2.  [Pathogenesis of diabetic foot disease].

Authors:  E Chantelau
Journal:  Internist (Berl)       Date:  1999-10       Impact factor: 0.743

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Review 4.  An evidence-based approach to diabetic foot infections.

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5.  Therapy of soft tissue infections with piperacillin/tazobactam.

Authors:  H Tassler; W Cullmann; D Elhardt
Journal:  J Antimicrob Chemother       Date:  1993-01       Impact factor: 5.790

6.  Determination of tazobactam and piperacillin in human plasma, serum, bile and urine by gradient elution reversed-phase high-performance liquid chromatography.

Authors:  A P Ocampo; K D Hoyt; N Wadgaonkar; A H Carver; C V Puglisi
Journal:  J Chromatogr       Date:  1989-11-10

7.  Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans.

Authors:  Christian Joukhadar; Heino Stass; Ulrike Müller-Zellenberg; Edith Lackner; Florian Kovar; Erich Minar; Markus Müller
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

Review 8.  Microdialysis--principles and applications for studies in animals and man.

Authors:  U Ungerstedt
Journal:  J Intern Med       Date:  1991-10       Impact factor: 8.989

Review 9.  Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid.

Authors:  William A Craig
Journal:  Infect Dis Clin North Am       Date:  2003-09       Impact factor: 5.982

10.  Penetration of piperacillin and tazobactam into pneumonic human lung tissue measured by in vivo microdialysis.

Authors:  Florian Tomaselli; Peter Dittrich; Alfred Maier; Michael Woltsche; Veronika Matzi; Johannes Pinter; Stephan Nuhsbaumer; Hans Pinter; Josef Smolle; Freyja M Smolle-Jüttner
Journal:  Br J Clin Pharmacol       Date:  2003-06       Impact factor: 4.335
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Journal:  Curr Infect Dis Rep       Date:  2009-09       Impact factor: 3.725

4.  Silver Sulfadiazine Eradicates Antibiotic-Tolerant Staphylococcus aureus and Pseudomonas aeruginosa Biofilms in Patients with Infected Diabetic Foot Ulcers.

Authors:  Enea Gino Di Domenico; Barbara De Angelis; Ilaria Cavallo; Francesca Sivori; Fabrizio Orlandi; Margarida Fernandes Lopes Morais D'Autilio; Chiara Di Segni; Pietro Gentile; Maria Giovanna Scioli; Augusto Orlandi; Giovanna D'Agosto; Elisabetta Trento; Daniela Kovacs; Giorgia Cardinali; Annunziata Stefanile; Tatiana Koudriavtseva; Grazia Prignano; Fulvia Pimpinelli; Ilaria Lesnoni La Parola; Luigi Toma; Valerio Cervelli; Fabrizio Ensoli
Journal:  J Clin Med       Date:  2020-11-25       Impact factor: 4.241

5.  Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection.

Authors:  Bianca L Price; Andrew M Lovering; Frank L Bowling; Curtis B Dobson
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

6.  Susceptibility of monomicrobial or polymicrobial biofilms derived from infected diabetic foot ulcers to topical or systemic antibiotics in vitro.

Authors:  Bianca L Price; Robert Morley; Frank L Bowling; Andrew M Lovering; Curtis B Dobson
Journal:  PLoS One       Date:  2020-02-18       Impact factor: 3.240
  6 in total

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