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Literature DB >> 16187828

Behavioral changes induced in rats by exposure to trimethylthiazoline, a component of fox odor.

Thomas Endres¹, Raimund Apfelbach, Markus Fendt.

Abstract

Trimethylthiazoline (TMT), a component of fox feces, has been used in various studies as a natural predator stimulus to induce autonomic and behavioral signs of fear (e.g., higher levels of stress hormones, freezing, and risk assessment). The present study investigated whether 2 further behavioral signs of fear are induced in rats by TMT exposure: potentiation of the acoustic startle response and inhibition of appetitive behavior. In addition, the authors tested the rats for dose dependency of TMT-induced freezing behavior. The study confirmed that behavioral changes observed during TMT exposure are caused by TMT-induced fear and are dose dependent. (c) 2005 APA

Entities: Chemical Disease Species

Mesh：

Substances：
Thiazoles

Year: 2005 PMID： 16187828 DOI： 10.1037/0735-7044.119.4.1004

Source DB: PubMed Journal: Behav Neurosci ISSN： 0735-7044 Impact factor: 1.912

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Cited

13 in total

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5. Odor preferences shape discrimination learning in rats.

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Review 6. The smell of fear: innate threat of 2,5-dihydro-2,4,5-trimethylthiazoline, a single molecule component of a predator odor.

Authors: Jeffrey B Rosen; Arun Asok; Trisha Chakraborty
Journal: Front Neurosci Date: 2015-08-25 Impact factor: 4.677

Behavioral changes induced in rats by exposure to trimethylthiazoline, a component of fox odor.

1. Calcitonin gene-related peptide in the bed nucleus of the stria terminalis produces an anxiety-like pattern of behavior and increases neural activation in anxiety-related structures.

2. Acid-sensing ion channel 1 contributes to normal olfactory function.

Review 3. Probing for Neuroadaptations to Unpredictable Stressors in Addiction: Translational Methods and Emerging Evidence.

4. Application of a naturalistic psychogenic stressor in periadolescent mice: effect on serum corticosterone levels differs by strain but not sex.

5. Odor preferences shape discrimination learning in rats.

Review 6. The smell of fear: innate threat of 2,5-dihydro-2,4,5-trimethylthiazoline, a single molecule component of a predator odor.

7. The olfactory hole-board test in rats: a new paradigm to study aversion and preferences to odors.

Review 8. Olfactory systems and neural circuits that modulate predator odor fear.

Review 9. Are single odorous components of a predator sufficient to elicit defensive behaviors in prey species?

10. Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse.